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Handgrip Strength as a Predictor of Chronic Kidney Disease Among Middle-Aged and Older Population: The TCLSIH and UK Biobank Cohort Studies
28 Pages Posted: 16 May 2022
More...Abstract
Background: Myokines released by muscles play an important role in regulating kidney function. However, no cohort study examined the association between handgrip strength (HGS, an indicator of muscle functions) and the incidence of chronic kidney disease (CKD). The aim of the prospective cohort study was to investigate how HGS is associated with incident CKD in two large cohort studies.
Methods: The TCLSIH cohort study included 15,612 participants who were recruited from Tianjin, China from 2013 to 2019, and the UK Biobank cohort study includes 440,619 participants who were recruited from 22 assessment centers across the UK taken between 2006 and 2010. All participants were free of CKD at baseline. CKD was defined as eGFR <60 ml/min/1·73 m2 or albumin-creatinine ratio ≥30mg/g or as having a clinical diagnosis of CKD. HGS was measured using a hydraulic handheld dynamometer.
Findings: The incidence rate of CKD 195 and 248 per 100,000 person-years in TCLSIH and UK Biobank, respectively. Consistent associations between HGS and incident CKD were observed in the TCLSIH cohort and UK Biobank, and the multivariate adjusted HRs (95% CI) of the incidence of CKD for absolute HGS were: 0·957 (0·929, 0·985) (P <0·01) and 0·985 (0·983, 0·988) (P <0·0001), respectively. Similar results for the association between weight-adjusted HGS and incident CKD in the two cohorts.
Interpretation: The present study firstly demonstrated that high absolute and weight-adjusted HGS were significantly associated with low risk of incident CKD from two large cohort studies in China and UK.
Funding: This work was supported by grants from the National Natural Science Foundation of China (No. 81673166), China.
Declaration of Interest: The authors declare that they have no competing interests.
Ethical Approval: This study was approved by the Institutional Review Board and ethical committee of the Tianjin Medical University and all participants gave written informed consent prior to participation.
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