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A Comparative Study of the Anti-Fatigue Activity of Extracts from Different Parts of Cistanche Tubulosa

21 Pages Posted: 31 May 2022 Publication Status: Under Review

See all articles by Yizhou Liu

Yizhou Liu

Beijing University of Chinese Medicine

Junjun Li

Beijing University of Chinese Medicine

Xiangning Liu

Beijing University of Chinese Medicine

Gang Wang

Beijing University of Chinese Medicine

Lingwen Cui

Beijing University of Chinese Medicine

Yuhan Zhao

China Academy of Chinese Medical Sciences

Yuqing Zhang

China Academy of Chinese Medical Sciences

Yang Li

China Academy of Chinese Medical Sciences

Qixin Wang

China Academy of Chinese Medical Sciences

Chun Li

Beijing University of Chinese Medicine

Peng-fei Tu

Beijing University of Chinese Medicine - Modern Research Center for Traditional Chinese Medicine

Abstract

Chronic fatigue syndrome (CFS), affects exercise capacity, learning and memory function, thereby decreasing work efficiency and increasing the number of accidents. Cistanche tubulosa, is a traditional Chinese medicine that has been used as a yang-tonic herb but the active components for its anti-fatigue effect remain unknown. Therefore, this study established sleep deprivation and forced swimming fatigue models to investgate pharmacological effects of three different extracts in Cistanche tubulosa on central and exercise-induced fatigue. Behavioral tests showed that treatment with different Cistanche extracts improved exercise capacity, learning and memory function to various degrees. Cistanche total oligosaccharides significantly increased ACTH, CHE, TSH levels and attenuated COR in the serum of central fatigue mice, attenuated 5-HT and NE levels in the hypothalamus and 5-HE, E levels in the brain, increased the storage of glycogen in liver and muscle, increased the level of SOD, SDH, reducing LD, BUN and MDA levels in the exercise fatigue mice. Compared to oligosaccharides, total polysaccharides could not regulate COR, CHE, and NE levels in the central fatigue mice, and could not regulate hepatic glycogen and MDA levels in the exercise fatigue mice. Meanwhile, phenylethanoid glycoside was only able to modulate the levels of ACTH, TSH, and NE in the centrally fatigued mice, and LD, MDA, and SOD in the exercise fatigued mice. Combined with the behavioral observation of central fatigue and exercise fatigue and the detection of various biochemical indexes, we found that the anti-fatigue effect of total oligosaccharides of Cistanche tubulosa is the most prominent and comprehensive.

Funding Information: This work was supported by the National Key Research and Development Program of China [grant number 2017YFC1702400].

Conflict of Interests: The authors declare that there is no conflict of interest.

Ethical Approval: All animal experimental protocols in this study were approved by the Animal Ethics Committee of Beijing University of Chinese Medicine (approval number “BUCM-4-2021113003-4081”)

Keywords: Cistanche tubulosa, anti-fatigue, central fatigue, exercise fatigue, Oligosaccharides

Suggested Citation

Liu, Yizhou and Li, Junjun and Liu, Xiangning and Wang, Gang and Cui, Lingwen and Zhao, Yuhan and Zhang, Yuqing and Li, Yang and Wang, Qixin and Li, Chun and Tu, Peng-fei, A Comparative Study of the Anti-Fatigue Activity of Extracts from Different Parts of Cistanche Tubulosa. Available at SSRN: https://ssrn.com/abstract=4124030 or http://dx.doi.org/10.2139/ssrn.4124030

Yizhou Liu (Contact Author)

Beijing University of Chinese Medicine ( email )

Beijing, 100029
China

Junjun Li

Beijing University of Chinese Medicine ( email )

Beijing, 100029
China

Xiangning Liu

Beijing University of Chinese Medicine ( email )

Beijing, 100029
China

Gang Wang

Beijing University of Chinese Medicine ( email )

Beijing, 100029
China

Lingwen Cui

Beijing University of Chinese Medicine ( email )

Beijing, 100029
China

Yuhan Zhao

China Academy of Chinese Medical Sciences ( email )

Dongcheng District
Beijing 100700
China

Yuqing Zhang

China Academy of Chinese Medical Sciences ( email )

Dongcheng District
Beijing 100700
China

Yang Li

China Academy of Chinese Medical Sciences ( email )

Dongcheng District
Beijing 100700
China

Qixin Wang

China Academy of Chinese Medical Sciences ( email )

Dongcheng District
Beijing 100700
China

Chun Li

Beijing University of Chinese Medicine ( email )

Beijing, 100029
China

Peng-fei Tu

Beijing University of Chinese Medicine - Modern Research Center for Traditional Chinese Medicine ( email )

Beijing
China

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