Cyanine Scaffold as Dual-Channel Colorimetric and Near Infra-Red Emitting Probe for Sensitive Detection of Phosgene in Environment and Live Cell

Abstract

Chemical warfare agent (CWA’s) detection in real time is obligatory in order to ease the threatening effect of these acute toxic agents to humankind. Herein, firstly we attempted, reversible, colorimetric, and fluorescent detection of phosgene in aqueous system succinctly described based on cyanine scaffold. Rapid and dual response of the probe was constructively employed to monitor the phosgene in the environment by strip test and soil analysis. The probe provides up to ppb (LOD of 0.02 ppb) level detection of phosgene with disticnt colour and fluoescence change. The turn-on near infra-red (NIR) fluorescence response bring in to play effectively to image trace level phosgene in living cells by fluorescent bio-imaging application.

Keywords: fluorescence bio-imaging, NIR emission, Phosgene, strip test, soil analysis