Yeast Nucleosomes: Cg Dinucleotide Function And its Special Role on Nucleosome Positioning

22 Pages Posted: 22 Jun 2022

See all articles by Jianli Liu

Jianli Liu

China University of Geosciences (CUG) - School of Water Resources and Environment and Research Center of Environmental Science and Engineering

Deliang Zhou

Beijing Zhongdian Yida Technology Co., Ltd.

Abstract

k-mers containing the CG dinucleotide could represent a special class, and impact the nucleosome positioning. We preprocessed two types of DNA in 16 chromosome of yeast: ‘core DNA’ and ‘linker DNA’ for motif numbers distribution of three subsets of 8-mer (XY0, XY1 and XY2) based on dinucleotides classification. As well, content differences of specific dinucleotides were analyzed in core/linker DNA of 16 chromosome. Results showed that: 1) CG dinucleotides could be a specific signal region of DNA to drive the separation of core DNA from linker DNA; 2) trimodal distribution of CG dinucleotide in core DNA showed impact on nucleosome positioning; 3) relative higher CG density in linker DNA was conducive to the improvement of transcriptional activity; 4) CA/GA/TG dinucleotides could also separate core DNA from linker DNA, but inferior to CG dinucleotide. Results are of great biological significance for nucleosome positioning and function and evolution of DNA sequences.

Keywords: CG dinucleotide, Motif number, 8-mers, nucleosome positioning, Core/Linker DNA

Suggested Citation

Liu, Jianli and Zhou, Deliang, Yeast Nucleosomes: Cg Dinucleotide Function And its Special Role on Nucleosome Positioning. Available at SSRN: https://ssrn.com/abstract=4143268 or http://dx.doi.org/10.2139/ssrn.4143268

Jianli Liu (Contact Author)

China University of Geosciences (CUG) - School of Water Resources and Environment and Research Center of Environmental Science and Engineering ( email )

29 Xueyuan Road
Beijing, 100083
China

Deliang Zhou

Beijing Zhongdian Yida Technology Co., Ltd. ( email )

Beijing
China

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