Novel Self-Assembly Nano Osa Starch Micelles Controlled by Protonation in Aqueous Media

Abstract

A new micellization method was applied to produce the nano OSA starch micelles with controllable size. The underlying mechanism was explored by using FT-IR, NMR, dynamic light scattering, zeta-potential, surface tension, fluorescence spectra and TEM. Due to the new starch modification method, the electrostatic repulsion between deprotonation carboxyl groups prevented the aggregation of starch chains. With the progress of protonation, weaken electrostatic repulsion and enhanced hydrophobic interaction driven the self-assembly of micelles. The size of micelles increased gradually with the increase of the PD and concentration of OSA starch. However, a V-shaped trends were observed in the size as the increase of DS. Curcuma loading test indicated that micelles had good encapsulated capability and the maximum value was 52.2 μg/mg. The understanding of the self-assembly behavior of OSA starch micelles can facilitate and improve the starch-based carrier designs used to synthesis complex and smart micelle delivery system with good biocompatibility.

Keywords: OSA starch, Starch micelle, self-assembly, Size, Molecular interactions, Curcumin