Insect Nephrocyte Function is Regulated by a Store Operated Calcium Entry Mechanism Controlling Endocytosis

32 Pages Posted: 18 Jul 2022

See all articles by Sara Miellet

Sara Miellet

affiliation not provided to SSRN

Shruthi Sivakumar

Bournemouth University

Charlotte Clarke

Bournemouth University

Paul Hartley

Bournemouth University

Abstract

Insect nephrocytes are ultrafiltration cells that remove circulating proteins and exogenous toxins from the haemolymph. Experimental disruption of nephrocyte development or function leads to systemic impairment of insect physiology as evidenced by cardiomyopathy, chronic activation of immune signalling and shortening of lifespan. The genetic and structural basis of the nephrocyte’s ultrafiltration mechanism is conserved between arthropods and mammals, making them an attractive model for studying human renal function and systemic clearance mechanisms in general. Although dynamic changes to intracellular calcium are fundamental to the function of many cell types, there are currently no studies of intracellular calcium signalling in nephrocytes.

Keywords: Drosophila, circulation, nephrocytes, signalling, calcium

Suggested Citation

Miellet, Sara and Sivakumar, Shruthi and Clarke, Charlotte and Hartley, Paul, Insect Nephrocyte Function is Regulated by a Store Operated Calcium Entry Mechanism Controlling Endocytosis. Available at SSRN: https://ssrn.com/abstract=4166070 or http://dx.doi.org/10.2139/ssrn.4166070

Sara Miellet

affiliation not provided to SSRN

Shruthi Sivakumar

Bournemouth University ( email )

Fern Barrow
Poole BH12 5BB, BH8 8EB
United Kingdom

Charlotte Clarke

Bournemouth University ( email )

Fern Barrow
Poole BH12 5BB, BH8 8EB
United Kingdom

Paul Hartley (Contact Author)

Bournemouth University ( email )

Fern Barrow
Poole BH12 5BB, BH8 8EB
United Kingdom

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