Download This PaperAnalysis of Notch1 Signaling in Mammalian Sperm Development
19 Pages Posted: 21 Jul 2022
Abstract
Highlights● The Delta-Notch signaling component Hes1 was expressed in Sertoli cells but not in the sperm cell lineage.● A transgenic reporter mouse study revealed no Notch1 signal in the sperm cell lineage.● Single-cell RNA sequencing of testes from mice and humans revealed Notch1 expression in Sertoli cells but not in sperm cells.
Keywords: Cre/loxP system, Delta-Notch signaling pathway, Gal4-UAS system, single-cell RNA-sequencing, testis
Suggested Citation: Suggested Citation
Sambe, Naoto and Yoshihara, Masaharu and Nishino, Teppei and Sugiura, Ryosuke and Nakayama, Takahiro and Louis, Chandra and Takahashi, Satoru, Analysis of Notch1 Signaling in Mammalian Sperm Development. Available at SSRN: https://ssrn.com/abstract=4169064 or http://dx.doi.org/10.2139/ssrn.4169064
Do you have a job opening that you would like to promote on SSRN?
Feedback
Feedback to SSRN
If you need immediate assistance, call 877-SSRNHelp (877 777 6435) in the United States, or +1 212 448 2500 outside of the United States, 8:30AM to 6:00PM U.S. Eastern, Monday - Friday.