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Joint Associations of Physical Activity and Body Mass Index with Incident Cardiovascular Diseases in Chinese Adults: A 13-Year Prospective Study in the Kailuan Cohort
34 Pages Posted: 27 Jul 2022
More...Abstract
Background: Active physical activity (PA) and ideal body mass index (BMI) are associated with a decreased risk of cardiovascular diseases (CVDs). However, whether PA can mediate the risk of CVDs contributing to obesity remains unclear.
Methods: We included 90,864 participants without baseline CVDs from the Kailuan study and prospectively investigated the association of BMI-PA with incident CVDs. The hazard ratio (HR) and 95% confidence interval (CI) for CVDs was estimated using the Cox proportional hazards model and time-dependent model.
Findings: During a median follow-up of 13·01 years, 6,437 incident CVDs were recorded. Compared with normal weight and active PA (NWAPA) participants, the HR for CVDs was 1·04 (95% CI: 0·93-1·17) in the normal weight and moderate PA (NWMPA), 0·84 (95% CI: 0·69-1·02) in the normal weight and inactive PA (NWIPA), 1·21 (95% CI: 1·06-1·38) in the overweight and active PA (OWAPA), 1·28 (95% CI: 1·14-1·43) in the overweight and moderate PA (OWMPA), 1·15 (95% CI: 0·97-1·36) in the overweight and inactive PA (OWIPA), 1·30 (95% CI: 1·11-1·53) in the obesity and active PA (OAPA), 1·53 (95% CI: 1·36-1·72) in the obesity and moderate PA (OMPA), and 1·66 (95% CI: 1·36-2·03) in the obesity and inactive PA (OIPA). These sensitivity analyses yielded similar results.
Interpretation: Participants with active PA did not appear to mitigate the excess risk of CVD associated with elevated BMI. Consequently, active PA that can alter body weight status could substantially benefit from cardiovascular events.
Funding Information: This work was supported by the National Natural Science Foundation of China (81673247, 81561128020).
Declaration of Interests: The authors have declared that no conflict of interest exists.
Ethics Approval Statement: This study was approved by the ethics committees of Kailuan General Hospital. A written informed consent form was obtained from all participants.
Suggested Citation: Suggested Citation