Development of a Porous Layer-by-Layer Microsphere with Branched Aliphatic Hydrocarbon Porogens

33 Pages Posted: 12 Aug 2022

See all articles by Farah Shahjin

Farah Shahjin

University of Nebraska at Omaha - Department of Pharmacology and Experimental Neuroscience

Milankumar Patel

University of Nebraska at Omaha - Department of Pharmacology and Experimental Neuroscience

Mahmudul Hasan

University of Nebraska Medical Center

Jacob D. Cohen

University of Nebraska at Omaha - Department of Pharmacology and Experimental Neuroscience

Farhana Islam

University of Nebraska Medical Center

MD Ashaduzzaman

University of Nebraska at Omaha

Mohammad Ullah Nayan

University of Nebraska at Omaha - Department of Pharmacology and Experimental Neuroscience

Mahadevan Subramaniam

University of Nebraska at Omaha

You Zhou

University of Nebraska at Lincoln

Irene Andreu

University of Rhode Island

Howard Eliot Gendelman

University of Nebraska at Omaha - Department of Pharmacology and Experimental Neuroscience

Bhavesh D. Kevadiya

University of Nebraska at Omaha - Department of Pharmacology and Experimental Neuroscience

Abstract

Porous polymer microspheres are designed, prepared, and deployed for the co-delivery of biotherapeutics, for tissue engineering and for regenerative medicine. In pharmaceutical science, particle parameters such as porosity dictate the particle characteristics and downstream utility by influencing the material tuning and biodegradation, cargo encapsulation and release. However, the regulation of these particle parameters, including pore uniformity and size, remains challenging. Porogens serve as a regulatory method assess how polymer-pore morphology affects the microsphere’s physicochemical properties. Herein, we characterize a six branched aliphatic hydrocarbon-based porogen(s) formulated to create pores in single and multilayered microspheres. The effects of the porogens on porous multilayered microspheres composed of biocompatible polycaprolactone, poly(lactic-co-glycolic acid) and polylactic acid polymers were evaluated. These porous multilayered microspheres can potentially serve as platforms for controlled and effective drug delivery as well as antimicrobial immunization.

Keywords: Layer-by-layer, Porous microspheres, Solvent evaporation, Polylactide, Poly(-caprolactone), Poly(glycolide-co-lactide), Polylactic acid

Suggested Citation

Shahjin, Farah and Patel, Milankumar and Hasan, Mahmudul and Cohen, Jacob D. and Islam, Farhana and Ashaduzzaman, MD and Nayan, Mohammad Ullah and Subramaniam, Mahadevan and Zhou, You and Andreu, Irene and Gendelman, Howard Eliot and Kevadiya, Bhavesh D., Development of a Porous Layer-by-Layer Microsphere with Branched Aliphatic Hydrocarbon Porogens. Available at SSRN: https://ssrn.com/abstract=4189034 or http://dx.doi.org/10.2139/ssrn.4189034

Farah Shahjin

University of Nebraska at Omaha - Department of Pharmacology and Experimental Neuroscience ( email )

Milankumar Patel

University of Nebraska at Omaha - Department of Pharmacology and Experimental Neuroscience ( email )

Mahmudul Hasan

University of Nebraska Medical Center ( email )

Jacob D. Cohen

University of Nebraska at Omaha - Department of Pharmacology and Experimental Neuroscience ( email )

Farhana Islam

University of Nebraska Medical Center ( email )

MD Ashaduzzaman

University of Nebraska at Omaha ( email )

Mohammad Ullah Nayan

University of Nebraska at Omaha - Department of Pharmacology and Experimental Neuroscience ( email )

Mahadevan Subramaniam

University of Nebraska at Omaha ( email )

You Zhou

University of Nebraska at Lincoln ( email )

730 N. 14th Street

Irene Andreu

University of Rhode Island ( email )

Quinn Hall
55 Lower College Rd.
Kingston, RI 02881
United States

Howard Eliot Gendelman (Contact Author)

University of Nebraska at Omaha - Department of Pharmacology and Experimental Neuroscience

Bhavesh D. Kevadiya

University of Nebraska at Omaha - Department of Pharmacology and Experimental Neuroscience ( email )

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