Development of a Porous Layer-by-Layer Microsphere with Branched Aliphatic Hydrocarbon Porogens
33 Pages Posted: 12 Aug 2022
Porous polymer microspheres are designed, prepared, and deployed for the co-delivery of biotherapeutics, for tissue engineering and for regenerative medicine. In pharmaceutical science, particle parameters such as porosity dictate the particle characteristics and downstream utility by influencing the material tuning and biodegradation, cargo encapsulation and release. However, the regulation of these particle parameters, including pore uniformity and size, remains challenging. Porogens serve as a regulatory method assess how polymer-pore morphology affects the microsphere’s physicochemical properties. Herein, we characterize a six branched aliphatic hydrocarbon-based porogen(s) formulated to create pores in single and multilayered microspheres. The effects of the porogens on porous multilayered microspheres composed of biocompatible polycaprolactone, poly(lactic-co-glycolic acid) and polylactic acid polymers were evaluated. These porous multilayered microspheres can potentially serve as platforms for controlled and effective drug delivery as well as antimicrobial immunization.
Keywords: Layer-by-layer, Porous microspheres, Solvent evaporation, Polylactide, Poly(-caprolactone), Poly(glycolide-co-lactide), Polylactic acid
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