Association between Parents Experiencing Ongoing Problems from COVID-19 and Adolescents Reporting Long COVID Six Months after a Positive or Negative SARS-CoV-2 PCR-Test: Prospective, National Cohort Study in England

Abstract

In a national cohort of 12,788 adolescents, those reporting parents experiencing ongoing problems from COVID-19 had 1.79-fold (95%CI: 1.58-2.02) higher odds of experiencing LONG COVID 6 months after a SARS-CoV-2 PCR-test than those reporting parents without ongoing symptoms, independent of age, sex, deprivation and SARS-CoV-2 infection status.

Note:
Funding Information: This work was supported by the Department of Health and Social Care, in their capacity as the National Institute for Health Research (NIHR), and by the UK Research and Innovation (UKRI) who have awarded funding grant number COVLT0022. All research at Great Ormond Street Hospital NHS Foundation Trust and UCL Great Ormond Street Institute of Child Health is made possible by the NIHR Great Ormond Street Hospital Biomedical Research Centre. SMPP is supported by a UK Medical Research Council Career Development Award (ref: MR/P020372/1).

Conflict of Interests: TS is Chair of the Health Research Authority and therefore recused himself from the research ethics application. All other authors declare no competing interests.

Ethical Approval: The study was approved by Yorkshire and the Humber–South Yorkshire Research Ethics Committee (REC reference: 21/YH/0060; IRAS project ID: 293495). UKHSA has legal permission, provided by Regulation 3 of The Health Service (Control of Patient Information) Regulations 2002, to process patient confidential information for national surveillance of communicable diseases. Individual patient consent is not required for initial invitation to the study.

Keywords: LONG COVID, SARS-CoV-2, children and young people, matched cohort study