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Using Probiotics to Alleviate Constipation Symptoms in Parkinson Patients: A Systematic Review and Meta-Analysis

17 Pages Posted: 7 Sep 2022 Publication Status: Published

See all articles by Nasibeh Ghalandari

Nasibeh Ghalandari

Shahid Beheshti University of Medical Sciences - School of Pharmacy

Farhad Assarzadegan

Shahid Beheshti University - School of Medicine

Hossein Mahdavi

Shahid Beheshti University of Medical Sciences

Elham Jamshidi

Shahid Beheshti University of Medical Sciences - Neuroscience Research Center

Hadi Esmaily

Shahid Beheshti University of Medical Sciences - School of Pharmacy

Abstract

Objectives: Parkinson Disease (PD) with clinical symptoms like rigidity, bradykinesia, and resting tremor, is a neurodegenerative disease. Constipation is a common complaint reported from PD patients. Probiotics have been widely used for managing functional constipation. The suggested mechanisms of PD related constipation are different. Enteric nervous system dysfunction due to alpha synuclein aggregation, puborectalis muscle dyssynergic contractions, and gut microbiome alterations are understood mechanisms in PD related constipation. This study is aimed to evaluate the effects of probiotic consumption on constipation management of PD patients by analyzing the pooled data of published randomized clinical trials (RCT).

Method: Scopus, PubMed, and Web of Science were searched for any published articles regarding Parkinson, Probiotic, and Constipation. From 944 studies, randomized-control trials were chosen from which, 3 were eligible for analysis. The common index in all selected articles was frequency of defecation per week. The outcomes were extracted, pooled and analyzed as means and standard deviations.

Result: To achieve the standardized mean difference (SMD) of treatment regarding frequency of defecation per week in controlled studies, we pooled data and calculated an SMD of 0.92 (95% CI, 0.65 to 1.19; I-squared = 57.0%; p < 0.001).

Conclusion: In this study, results showed favorable effects of probiotic in PD patients suffering from constipation. Future multicenter studies are needed, focusing on long term efficacy and safety.

Funding Statement: This research received no external funding.

Declaration of Interests: The authors declare no conflict of interests.

Keywords: Parkinson, constipation, Probiotic, Gastrointestinal Microbiome, Neurodegenerative diseases

Suggested Citation

Ghalandari, Nasibeh and Assarzadegan, Farhad and Mahdavi, Hossein and Jamshidi, Elham and Esmaily, Hadi, Using Probiotics to Alleviate Constipation Symptoms in Parkinson Patients: A Systematic Review and Meta-Analysis. Available at SSRN: https://ssrn.com/abstract=4199878 or http://dx.doi.org/10.2139/ssrn.4199878

Nasibeh Ghalandari

Shahid Beheshti University of Medical Sciences - School of Pharmacy ( email )

Farhad Assarzadegan

Shahid Beheshti University - School of Medicine ( email )

Hossein Mahdavi

Shahid Beheshti University of Medical Sciences ( email )

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Elham Jamshidi

Shahid Beheshti University of Medical Sciences - Neuroscience Research Center ( email )

Hadi Esmaily (Contact Author)

Shahid Beheshti University of Medical Sciences - School of Pharmacy ( email )

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