Evaluation of Toxicity of the Bioactive Components from the Stem of Buyo (Piper betle L.) Extracts

Abstract

Extracts of Buyo (Piper betle L) were subjected to a bioscreening study to detect cytotoxicity activity by the brine shrimp lethality bioassay. Specifically, the researchers opted to use the stem part of the plant since there has been no study about its cytotoxic activity. The result obtained for the ethanol extract was promising. The researchers concluded that ethanol extract is the most active in cytotoxicity activity, with a value of 205.3525, against the other extracts. This extract can be regarded as a promising candidate for a plant-derived antitumor or anticancer compound. Also, it is suggested that the extracts should be subjected to other tests and further experimentations to elaborate on its essential biological properties.

Keywords: Brine Shrimp Lethality Test, Cytotoxicity, Piper betle L., Medicinal Properties, Green Heart