Malate-Based Polyester Chemically Shielded Metal–Phenolic Networks Coated with Long-Lasting Antimicrobial and Anti-Inflammatory Performance for Infection Prevention in Artificial Hair Fibers

38 Pages Posted: 22 Sep 2022

See all articles by Yue Li

Yue Li

Southern Medical University - Nanfang Hospital

Yong Miao

Southern Medical University - Nanfang Hospital

Lunan Yang

Southern Medical University - Nanfang Hospital

Gaofeng Wang

Southern Medical University - Nanfang Hospital

Meimei Fu

Southern Medical University

Yue Wang

Southern Medical University

Danlan Fu

Southern Medical University - Nanfang Hospital

Junfei Huang

Southern Medical University - Nanfang Hospital

Jin Wang

Southern Medical University - Nanfang Hospital

Zhexiang Fan

Southern Medical University - Nanfang Hospital

Zhihui Lu

Huangpu Institute of Materials

Jinshan Guo

Southern Medical University - School of Basic Medical Sciences

Zhiqi Hu

Southern Medical University - Nanfang Hospital

Abstract

Microbially induced peri-implant infection and dislodgement are among the most common complications of implant surgery. Most existing medical implant surfaces lack long-lasting antimicrobial capacity and are adversely affected by excessive reactive oxygen species production or burst release of antimicrobial agents within short periods. This study aimed to perform in situ reduction and anchoring of silver nanoparticles (AgNPs) on polyamide surfaces pre-deposited with a tannic acid coating and their layer-by-layer self asesmbly. Through in situ reduction of silver ions (Ag + ) by plant-derived tannic acid, tannin-sliver (TA-Ag) metal–phenolic networks (MPNs) were deposited on polyamide layer-by-layer, and the remaining functionalities on the immobilized TA moieties were subsequently covalently linked to poly(1,8-octanediol L-malate) (POM), a malate-based biodegradable polymer. The AgNPs were effectively locked in the coating matrix comprising MPNs and POM via coordination bonds between Ag NPs and tannin and covalent crosslinks between tannin and POM, which slowed down the “burst release” of Ag NPs and extended the release time of Ag + (up to 56 days). The remarkable long-term antibacterial (>97%) and anti-inflammatory coating has promising widespread applications not only in artificial hair fibers but also in other medical implant applications.

Note:
Funding Information: This work was supported by the Natural Science Foundation of China [grant numbers: U21A2099, 82272453, 82102545, and 81971889] and the Natural Science Foundation of Guangdong Province [grant number 2019A1515012170].

Conflict of Interests: There are no competing interests to declare.

Ethical Approval: All animal experiments were performed according to protocols approved by the Animal Care and Use Committee of Southern Medical University (Guangzhou, China) (Approval number: NFYY- 2020-0929).

Keywords: metal-phenolic networks, antibacterial coating, silver, anti-inflammatory, malate-based polymer

Suggested Citation

Li, Yue and Miao, Yong and Yang, Lunan and Wang, Gaofeng and Fu, Meimei and Wang, Yue and Fu, Danlan and Huang, Junfei and Wang, Jin and Fan, Zhexiang and Lu, Zhihui and Guo, Jinshan and Hu, Zhiqi, Malate-Based Polyester Chemically Shielded Metal–Phenolic Networks Coated with Long-Lasting Antimicrobial and Anti-Inflammatory Performance for Infection Prevention in Artificial Hair Fibers. Available at SSRN: https://ssrn.com/abstract=4222719 or http://dx.doi.org/10.2139/ssrn.4222719

Yue Li

Southern Medical University - Nanfang Hospital ( email )

Yong Miao

Southern Medical University - Nanfang Hospital ( email )

Lunan Yang

Southern Medical University - Nanfang Hospital ( email )

Gaofeng Wang

Southern Medical University - Nanfang Hospital ( email )

Meimei Fu

Southern Medical University ( email )

Guangzhou
China

Yue Wang

Southern Medical University ( email )

Guangzhou
China

Danlan Fu

Southern Medical University - Nanfang Hospital ( email )

Junfei Huang

Southern Medical University - Nanfang Hospital ( email )

Jin Wang

Southern Medical University - Nanfang Hospital ( email )

Zhexiang Fan

Southern Medical University - Nanfang Hospital ( email )

Zhihui Lu

Huangpu Institute of Materials ( email )

Jinshan Guo (Contact Author)

Southern Medical University - School of Basic Medical Sciences ( email )

Zhiqi Hu

Southern Medical University - Nanfang Hospital ( email )

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