HIV-1 Nef Targeted Peptides as Antiretroviral Therapeutics: A Perspective
18 Pages Posted: 23 Nov 2022 Publication Status: Preprint
The rise of drug-resistant HIV strains and undetermined vaccine prospects substantiate the need for newer therapeutic approaches to target HIV infection. Peptide-based therapies are emerging as a promising field in HIV treatment. Extending our knowledge on protein-protein interactions attributed to HIV pathogenesis for improved drug development would be a significant undertaking. Nef, an accessory viral protein is a critical regulator of HIV pathogenesis and promotes immune evasion of infected cells. The current review focuses on some key HIV-Nef and host protein-protein interactions and proposes these as potential drug targets by inhibiting additional support of Nef in viral latency. The review also highlights the currently explored nano-based approaches in view of the diagnosis of HIV-1 infection and its effective therapeutics regime.
Funding Information: None.
Declaration of Interests: Authors declare no conflict of interests.
Keywords: HIV, Antiretroviral therapeutics, Nanomedicine, nano-diagnosis
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