HIV-1 Nef Targeted Peptides as Antiretroviral Therapeutics: A Perspective

The rise of drug-resistant HIV strains and undetermined vaccine prospects substantiate the need for newer therapeutic approaches to target HIV infection. Peptide-based therapies are emerging as a promising field in HIV treatment. Extending our knowledge on protein-protein interactions attributed to HIV pathogenesis for improved drug development would be a significant undertaking. Nef, an accessory viral protein is a critical regulator of HIV pathogenesis and promotes immune evasion of infected cells. The current review focuses on some key HIV-Nef and host protein-protein interactions and proposes these as potential drug targets by inhibiting additional support of Nef in viral latency. The review also highlights the currently explored nano-based approaches in view of the diagnosis of HIV-1 infection and its effective therapeutics regime.

Funding Information: None.

Declaration of Interests: Authors declare no conflict of interests.

Keywords: HIV, Antiretroviral therapeutics, Nanomedicine, nano-diagnosis

Suggested Citation: Suggested Citation

Singhal, Jaya and Agrawal, Nitesh Kumar and Sharma, Sumit Kumar and Awasthi, Amit and Tripathi, Rajkamal and Saxena, Reshu, HIV-1 Nef Targeted Peptides as Antiretroviral Therapeutics: A Perspective. Available at SSRN: https://ssrn.com/abstract=4254451 or http://dx.doi.org/10.2139/ssrn.4254451