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HIV-1 Nef Targeted Peptides as Antiretroviral Therapeutics: A Perspective

18 Pages Posted: 23 Nov 2022 Publication Status: Preprint

See all articles by Jaya Singhal

Jaya Singhal

King George’s Medical University

Nitesh Kumar Agrawal

University of Mumbai - Pillai College of Engineering

Sumit Kumar Sharma

Translational Health Science and Technology Institute

Amit Awasthi

Government of India - Immuno-biology Lab

Rajkamal Tripathi

CSIR-Central Drug Research Institute

Reshu Saxena

Translational Health Science and Technology Institute

Abstract

The rise of drug-resistant HIV strains and undetermined vaccine prospects substantiate the need for newer therapeutic approaches to target HIV infection. Peptide-based therapies are emerging as a promising field in HIV treatment. Extending our knowledge on protein-protein interactions attributed to HIV pathogenesis for improved drug development would be a significant undertaking. Nef, an accessory viral protein is a critical regulator of HIV pathogenesis and promotes immune evasion of infected cells. The current review focuses on some key HIV-Nef and host protein-protein interactions and proposes these as potential drug targets by inhibiting additional support of Nef in viral latency. The review also highlights the currently explored nano-based approaches in view of the diagnosis of HIV-1 infection and its effective therapeutics regime.

Funding Information: None.

Declaration of Interests: Authors declare no conflict of interests.

Keywords: HIV, Antiretroviral therapeutics, Nanomedicine, nano-diagnosis

Suggested Citation

Singhal, Jaya and Agrawal, Nitesh Kumar and Sharma, Sumit Kumar and Awasthi, Amit and Tripathi, Rajkamal and Saxena, Reshu, HIV-1 Nef Targeted Peptides as Antiretroviral Therapeutics: A Perspective. Available at SSRN: https://ssrn.com/abstract=4254451 or http://dx.doi.org/10.2139/ssrn.4254451

Jaya Singhal

King George’s Medical University ( email )

Nitesh Kumar Agrawal

University of Mumbai - Pillai College of Engineering ( email )

New Panvel
Navimumbai
Navi Mumbai, 410206
India

Sumit Kumar Sharma

Translational Health Science and Technology Institute ( email )

India

Amit Awasthi

Government of India - Immuno-biology Lab ( email )

Rajkamal Tripathi

CSIR-Central Drug Research Institute ( email )

Jankipuram Extension
Lucknow, UT 226031
India

Reshu Saxena (Contact Author)

Translational Health Science and Technology Institute ( email )

India

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