Ion-Exchange Driven Selenylation Engineering to Construct Ni(Oh)2@Cu2se Hetero-Nanocage Electrocatalysts for Advanced Glucose Sensing in Serum and Beverage

Abstract

In this work, Cu2Se nanosheets were coated on the surface of Ni(OH)2 nanocages (NCs) by an ion-exchange driven selenization strategy. The resulting Ni(OH)2@Cu2Se hollow heterostructures (Ni(OH)2@Cu2Se HHSs) manifested high electrical conductivity and electrocatalytic activities derived from synergistic effect of Ni and Cu phases, and the designed hierarchical structures enhanced glucose adsorption ability confirmed by the density function theory (DFT) calculations and robustness of the integrated nano-electrocatalyst. Remarkably, the Ni(OH)2@Cu2Se HHSs modified electrode excited superior glucose sensing behavior with a wide linear range of 0.001-7 mM, sensitivity up to 2420.4 μA mM-1 cm2, low limit of detection (LOD, 0.15 μM ), and fast response (less 2 s). Furthermore, Ni(OH)2@Cu2Se HHSs was promising to analyze glucose in real samples (serum and beverage) with competitive performances. Integrating copper selenide and Ni-based materials as 3D hollow heterostructures further expand the selection of electrocatalysts for highly sensitive glucose detection in food and biological samples.

Keywords: Selenization, Hollow heterostructures, Ni(OH)2@Cu2Se, DFT, Glucose detection