New Chromone Compounds from the Marine Derived Fungus Diaporthe Sp. Xw12-1

Abstract

Four new chromone compounds diaporspchromanones A−C (1−3) and diaporspchromanone H (4), together with three known compounds (5−7) were separated from the marine derived fungus Diaporthe sp. XW12-1. The structures of the new compounds, including their absolute configurations, were elucidated by extensive spectroscopic analysis and the Mosher’s ester method. Among them, diaporspchromanones A−C (1−3) possess a 3-substituted-chroman-4-one skeleton, which are rarely found in natural sources. In the bioassays, all compounds were evaluated for their inhibitory activity against lipopolysaccharide-activated nitric oxide (NO) production in RAW264.7 cells. Compounds 2 and 3 showed potent anti-inflammatory effects than the positive control (indomethacin, IC50, 70.33 ± 0.95 μM) with IC50 values of 19.06 ± 3.60 and 9.56 ± 0.18 μM, respectively.

Keywords: Chromone derivatives, marine derived fungi, Diaporthe sp., Anti-inflammatory activity