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Incidence, Mortality and Disability-Adjusted Life Years of Acute Myocardial Infarction in Kazakhstan: Data from Unified National Electronic Healthcare System 2014-2019

16 Pages Posted: 1 Nov 2022

See all articles by Gulnur Zhakhina

Gulnur Zhakhina

Nazarbayev University - School of Medicine

Abduzhappar Gaipov

Nazarbayev University - School of Medicine

Alessandro Salustri

Nazarbayev University - School of Medicine

Arnur Gusmanov

Nazarbayev University - School of Medicine

Yesbolat Sakko

Nazarbayev University - School of Medicine

Sauran Yerdessov

Nazarbayev University - School of Medicine

Makhabbat Bekbossynova

National Research Cardiac Surgery Center

Anara Abbay

Nazarbayev University - School of Medicine

Antonio Sarría-Santamera

Nazarbayev University - School of Medicine

More...

Abstract

Background: Cardiovascular diseases contribute to premature death worldwide which leads to social and economic loss. According to the Global Burden of Disease Study data, in Kazakhstan, 714,104 disability-adjusted life years (DALYs) were lost between 1990 and 2017 from ischemic heart diseases. The aim of this study is to analyze separately the burden of acute myocardial infarction (AMI) in Kazakhstan and describe the outcome of hospitalized patients.

Methods: The data of 79,172 people admitted to hospital with ICD-10 diagnosis I21 between 2014-2019 was derived from the Unified National Electronic Health System of Kazakhstan and retrospectively analyzed.

Findings: The majority of the cohort (53,285, 67%) were men, Kazakh ethnicity (38,057, 48%), and had hypertension as a comorbidity (61,972, 78%). In males, a sharp increase in incidence is present after 40 years, while for females, the morbidity increases gradually after 55. During the observation period, all-cause mortality increased from 101 to 210 people per million population. In 2019, 169,862 age-adjusted DALYs were lost with a high proportional contribution (79%) of years of life lost due to premature death. Although the incidence is higher for men, they have better survival rates than women.

Interpretation: This research evaluated the burden and DALYs of AMI in Kazakhstan, the largest Central Asian country. The results show that more effective disease management systems and preventive measures at earlier ages are needed.

Funding Information: This study was supported by grants from the Nazarbayev University Faculty Development Research Grant Program FDCRGP 2020–2022 (Funder Project Reference: 240919FD3913.

Declaration of Interests: Gulnur Zhakhina, Abduzhappar Gaipov, Alessandro Salustri, Arnur Gusmanov, Yesbolat Sakko, Sauran Yerdessov, Makhabbat Bekbossynova, Anara Abbay, Antonio Sarria-Santamera declare no financial and competing conflicts.

Ethics Approval Statement: The study was approved by the Nazarbayev University Institutional Review Ethics Committee (NU-IREC 490/18112021), with exemption from informed consent.

Keywords: Cardiovascular disease, acute myocardial infarction, risk factor, survival analysis, disability-adjusted life-years.

Suggested Citation

Zhakhina, Gulnur and Gaipov, Abduzhappar and Salustri, Alessandro and Gusmanov, Arnur and Sakko, Yesbolat and Yerdessov, Sauran and Bekbossynova, Makhabbat and Abbay, Anara and Sarría-Santamera, Antonio, Incidence, Mortality and Disability-Adjusted Life Years of Acute Myocardial Infarction in Kazakhstan: Data from Unified National Electronic Healthcare System 2014-2019. Available at SSRN: https://ssrn.com/abstract=4264309 or http://dx.doi.org/10.2139/ssrn.4264309

Gulnur Zhakhina

Nazarbayev University - School of Medicine ( email )

Abduzhappar Gaipov (Contact Author)

Nazarbayev University - School of Medicine ( email )

Nur-Sultan City
Kazakhstan

Alessandro Salustri

Nazarbayev University - School of Medicine ( email )

Arnur Gusmanov

Nazarbayev University - School of Medicine ( email )

Yesbolat Sakko

Nazarbayev University - School of Medicine ( email )

Sauran Yerdessov

Nazarbayev University - School of Medicine ( email )

Makhabbat Bekbossynova

National Research Cardiac Surgery Center ( email )

Kazakhstan

Anara Abbay

Nazarbayev University - School of Medicine ( email )

Antonio Sarría-Santamera

Nazarbayev University - School of Medicine ( email )

Nur-Sultan City
Kazakhstan

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