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Neural Ensemble Dynamics in Trunk and Hindlimb Sensorimotor Cortex Encode for the Control of Postural Stability

24 Pages Posted: 5 Nov 2022 Publication Status: Review Complete

See all articles by Gregory Disse

Gregory Disse

University of California, Davis - Neuroscience Graduate Group

Bharadwaj Nandakumar

University of California, Davis - Department of Biomedical Engineering

Francois Philippe Pauzin

University of California, Davis - Department of Biomedical Engineering

Gary Howard Blumenthal

Drexel University - School of Biomedical Engineering

Zhaodan Kong

University of California, Davis - Department of Mechanical and Aerospace Engineering

Jochen Ditterich

University of California, Davis - Neuroscience Graduate Group

Karen Anne Moxon

University of California, Davis - Neuroscience Graduate Group

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Abstract

The cortex has a disputed role in monitoring postural equilibrium and intervening in cases of major postural disturbances. Here, we investigate the patterns of neural activity in the cortex that underlie neural dynamics during unexpected perturbations. In both the sensory (S1) and motor (M1) cortices of the rat, unique neuronal classes differentially covaried their response to distinguish different characteristics of applied postural perturbations; however, there was substantial information gain in M1, demonstrating a role for higher-order computations in motor control. Dynamical systems modeling of M1 revealed that these neuronal classes contribute to a low dimensional manifold consisting of separate subspaces that define different computations depending on the postural responses and are enabled by congruent and incongruent neural firing patterns. These results inform how the cortex engages in postural control, directing work aiming to understand postural instability after neurological disease.

Funding Information: This work was supported by NSF DARE grant 1993751 (K.A.M.), and NIH NCATS grant UL1 TR001860 and linked award TL1 TR001861 (G.D.D.).

Declaration of Interests: The authors declare no competing interests.

Ethics Approval Statement: All procedures and surgeries were approved by the UC Davis IACUC and followed ARRIVE Guidelines.

Keywords: Posture, cortex, Neural dynamics, Neural trajectories, Rat

Suggested Citation

Disse, Gregory and Nandakumar, Bharadwaj and Pauzin, Francois Philippe and Blumenthal, Gary Howard and Kong, Zhaodan and Ditterich, Jochen and Moxon, Karen Anne, Neural Ensemble Dynamics in Trunk and Hindlimb Sensorimotor Cortex Encode for the Control of Postural Stability. Available at SSRN: https://ssrn.com/abstract=4265015 or http://dx.doi.org/10.2139/ssrn.4265015
This version of the paper has not been formally peer reviewed.

Gregory Disse

University of California, Davis - Neuroscience Graduate Group

Bharadwaj Nandakumar

University of California, Davis - Department of Biomedical Engineering ( email )

Francois Philippe Pauzin

University of California, Davis - Department of Biomedical Engineering ( email )

Gary Howard Blumenthal

Drexel University - School of Biomedical Engineering ( email )

Zhaodan Kong

University of California, Davis - Department of Mechanical and Aerospace Engineering ( email )

Jochen Ditterich

University of California, Davis - Neuroscience Graduate Group ( email )

Karen Anne Moxon (Contact Author)

University of California, Davis - Neuroscience Graduate Group ( email )

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