Water-Induced Fluorescence Turn-On Imidazole Derivative and its Interactions with Bovine Serum Albumin

34 Pages Posted: 14 Nov 2022

See all articles by S. Behera

S. Behera

Veer Surendra Sai University of Technology

Pragyan Dash

Veer Surendra Sai University of Technology

P. Mohanty

Veer Surendra Sai University of Technology

R. Behura

Veer Surendra Sai University of Technology

Suban K. Sahoo

Sardar Vallabhbhai National Institute of Technology

Bigyan Ranjan Jali

Veer Surendra Sai University of Technology

Abstract

A new trityl imidazole derivative L was synthesized in one-step by reacting 1H-imidazole and triphenylmethyl chloride. The receptor L was applied for the detection of trace amount water in DMSO. The weakly emissive L in DMSO showed a significant fluorescence enhancement upon addition of water due to the suppression of photo-induced electron transfer process and aggregation-induced emission. The sensitivity of L to detect water in DMSO was estimated as 0.002 wt%. Further, the binding characteristic of L with BSA was explored by using steady state fluorescence, fluorescence anisotropy and fluorescence lifetime under physiological condition at pH 7. The formation of BSA-L complex quenched the fluorescence emission of BSA. The molecular docking analysis was performed to establish the stable BSA-L complex formed due the multiple non-covalent interactions occurred between the residues of BSA and the receptor L.

Keywords: Trityl imidazole, Water sensor, SEM, BSA, Molecular Docking

Suggested Citation

Behera, S. and Dash, Pragyan and Mohanty, P. and Behura, R. and Sahoo, Suban K. and Jali, Bigyan Ranjan, Water-Induced Fluorescence Turn-On Imidazole Derivative and its Interactions with Bovine Serum Albumin. Available at SSRN: https://ssrn.com/abstract=4265843 or http://dx.doi.org/10.2139/ssrn.4265843

S. Behera

Veer Surendra Sai University of Technology

Pragyan Dash

Veer Surendra Sai University of Technology

P. Mohanty

Veer Surendra Sai University of Technology

R. Behura

Veer Surendra Sai University of Technology

Suban K. Sahoo

Sardar Vallabhbhai National Institute of Technology

Bigyan Ranjan Jali (Contact Author)

Veer Surendra Sai University of Technology ( email )

VSSUT, Siddhi vihar, Burla
Burla
India

Do you have a job opening that you would like to promote on SSRN?

Paper statistics

Downloads
44
Abstract Views
86
PlumX Metrics