A Circadian Oscillator-Modulated Negative Feedback Produces Robust Circa‘Bi’Dian Rhythm

13 Pages Posted: 14 Nov 2022

Abstract

Two-day rhythms, known as circabidian (~48 h) rhythms, appear in various animal behaviors, including those of humans, mosquitos, and chafers. A circadian (~24 h) oscillator has been suggested to modulate another oscillator that generates circabidian rhythms. However, the mechanism through which oscillators generate circabidian rhythms remains largely unknown. Since many biological oscillators require a negative feedback loop (NFL), we hypothesized that an NFL may generate circabidian rhythms under some modulations by a circadian oscillator. Here, we theoretically examine this hypothesis using two model types for a circadian oscillator-modulated NFL. Depending on the time spent for NFL processes, these models reproduce representative experimental facts: (1) direct switching between circabidian and circadian rhythms; (2) circadian-like activity patterns, for long and short durations alternating every other day, instead of the obvious circabidian patterns. Direct switching and robust maintenance of circabidian rhythms require supra-threshold modulation by the circadian oscillator. These theoretical results demonstrated that the circadian oscillator-modulated NFL provides an experimentally verifiable oscillator that generates circabidian rhythms.

Keywords: Circabidian rhythm, Circadian rhythm, Negative feedback loop, Entrainment, Two-day rhythm, Synchronization

Suggested Citation

Ota, Teruya and Fujimoto, Koichi, A Circadian Oscillator-Modulated Negative Feedback Produces Robust Circa‘Bi’Dian Rhythm. Available at SSRN: https://ssrn.com/abstract=4268531 or http://dx.doi.org/10.2139/ssrn.4268531

Teruya Ota

Osaka University ( email )

1-1 Yamadaoka
Suita
Osaka, 565-0871
Japan

Koichi Fujimoto (Contact Author)

Osaka University ( email )

1-1 Yamadaoka
Suita
Osaka, 565-0871
Japan

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