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Early Osteoimmunomodulation by Mucin Hydrogels Augments the Healing and Revascularization of Rat Critical-Size Calvarial Bone Defects

27 Pages Posted: 24 Nov 2022 Publication Status: Published

See all articles by Song Chen

Song Chen

Soochow University

Huan Wang

Soochow University

Dachuan Liu

Soochow University

Jianzhong Bai

Soochow University

Havard J. Haugen

University of Oslo

Bin Li

Soochow University - Department of Orthopaedic Surgery

Hongji Yan

Royal Institute of Technology (KTH)

Abstract

The design principle of osteogenic bone grafts has shifted from immunological inertness to limiting foreign body response to combined osteoimmunomodulatory activity to promote high-quality endogenous bone regeneration. Recently developed immunomodulatory mucin hydrogels have been shown to elicit very low complement activation and suppress macrophage release and activation after implantation in vivo. However, their immunoregulatory activity has not yet been studied in the context of tissue repair. Herein, we synthesized mucin-monetite composite materials and investigated their early osteoimmunomodulation using a critical-size rat bone defect model. We demonstrated that the composites can downregulate the expressions of IL-8 and IL-1Ra, and polarize macrophages towards the M2 phenotype at weeks 1 and 2. The early osteoimmunomodulation enhanced early osteogenesis and angiogenesis and ultimately promoted fracture healing and engraftment (revascularization of the host vasculature) at weeks 6 and 12. Overall, we demonstrated the applicability of mucin-based immunomodulatory biomaterials to enhance tissue repair in tissue engineering and regenerative medicine.

Keywords: Mucin hydrogels, Monetite, osteoimmunomodulation, Vascularization

Suggested Citation

Chen, Song and Wang, Huan and Liu, Dachuan and Bai, Jianzhong and Haugen, Havard J. and Li, Bin and Yan, Hongji, Early Osteoimmunomodulation by Mucin Hydrogels Augments the Healing and Revascularization of Rat Critical-Size Calvarial Bone Defects. Available at SSRN: https://ssrn.com/abstract=4285355 or http://dx.doi.org/10.2139/ssrn.4285355

Song Chen

Soochow University ( email )

No. 1 Shizi Street
Taipei, 215006
Taiwan

Huan Wang

Soochow University ( email )

Dachuan Liu

Soochow University ( email )

No. 1 Shizi Street
Taipei, 215006
Taiwan

Jianzhong Bai

Soochow University ( email )

No. 1 Shizi Street
Taipei, 215006
Taiwan

Havard J. Haugen

University of Oslo ( email )

Bin Li (Contact Author)

Soochow University - Department of Orthopaedic Surgery ( email )

No. 1 Shizi Street
Taipei, Jiangsu 215006
Taiwan

Hongji Yan

Royal Institute of Technology (KTH) ( email )

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