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The Impact of Spousal Diabetes Status and Ideal Cardiovascular Health Metrics on Risk of Incident Diabetes: A Nationwide Prospective Cohort Study

33 Pages Posted: 27 Dec 2022

See all articles by Zhiyun Zhao

Zhiyun Zhao

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases

Qiuyu Cao

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases

Hong Lin

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases

Zhengnan Gao

Dalian University of Technology - Department of Endocrinology; Dalian University - Dalian Municipal Central Hospital

Min Xu

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases

Yu Xu

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases

Tiange Wang

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases

Mian Li

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases

Yuhong Chen

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases

Shuangyuan Wang

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases

Tianshu Zeng

Huazhong University of Science and Technology - Tongji Medical College

Ruying Hu

Zhejiang Provincial Center for Disease Control and Prevention - Department of Non-Communicable Disease Control and Prevention

Xue-Feng Yu

Huazhong University of Science and Technology - Tongji Medical College

Gang Chen

Fujian Medical University - Department of Endocrinology; Fujian Academy of Medical Sciences - Fujian Provincial Key Laboratory of Medical Analysis

Qing Su

Shanghai Jiao Tong University (SJTU) - Xinhua Hospital

Yiming Mu

Government of the People's Republic of China - Department of Endocrinology

Lulu Chen

Huazhong University of Science and Technology - Tongji Medical College

Xulei Tang

Lanzhou University - First Hospital

Li Yan

Sun Yat-Sen University (SYSU) - Department of Endocrinology

Guijun Qin

Zhengzhou University - Division of Endocrinology

Qin Wan

Southwest Medical University - Affiliated Hospital

Guixia Wang

Jilin University (JLU) - Department of Endocrinology and Metabolism

Feixia Shen

Wenzhou Medical University - First Affiliated Hospital

Zuojie Luo

Guangxi Medical University - First Affiliated Hospital

Yingfen Qin

Guangxi Medical University

Li Chen

Shandong University - Department of Endocrinology

Yanan Huo

Nanchang University - Jiangxi Provincial People’s Hospital

Qiang Li

Harbin Medical University - Second Affiliated Hospital

Zhen Ye

Zhejiang Provincial Center for Disease Control and Prevention

Yinfei Zhang

Central Hospital of Shanghai Jiading District

Chao Liu

Jiangsu Province Hospital on Integration of Chinese and Western Medicine

Youmin Wang

Anhui Medical University - First Affiliated Hospital

Shengli Wu

Karamay Municipal People's Hospital

Tao Yang

Nanjing Medical University - First Affiliated Hospital

Huacong Deng

Chongqing Medical University - First Affiliated Hospital

Jiajun Zhao

Shandong First Medical University - Science and Technology Innovation Center; Shandong First Medical University - Department of Endocrinology and Metabolism; Shandong Academy of Clinical Medicine - Institute of Endocrinology; Shandong Clinical Medical Center of Endocrinology and Metabolism

Lixin Shi

Affiliated Hospital of Guiyang Medical College

Guang Ning

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases

Jieli Lu

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases

Weiqing Wang

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases

yufang bi

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases

More...

Abstract

Background: Pairs of spouses share common socio-economic, environmental and lifestyle factors. Multiple studies found that spousal diabetes status was related to diabetes prevalence. We explored the influence of spousal diabetes status and cardiovascular health metrics on risk of incident diabetes in a prospective cohort study.

Methods: The study participants were from a population-based cohort which called China Cardiometabolic Disease and Cancer Cohort and followed up for 3.6 years. 34821 non-diabetes individuals who have completed their own and spouse's glucose information were involved in the study. Diabetes was defined according to 2010 American Diabetes Association standard criteria.

Findings: Spousal diabetes diagnosis was associated with increased risk of incident diabetes (HR=1.246 95%CI: 1.111-1.397). Further, participants whose spouses with uncontrolled HbA1c level had higher risk of diabetes (HR=1.299 95%CI: 1.121-1.504) and the risk of diabetes disappeared in the participants whose spouses with controlled HbA1c level (HR=1.180 95%CI: 0.996-1.399).  Moreover, individuals whose ideal cardiovascular health metrics (ICVHM) value was less than 4 were affected by their spouse's diabetes status, while individuals whose ICVHM value was 4 or more were not affected. Besides, those who had more components of ICVHMs than their spouses could avoid increase of diabetes risk associated with spouses’ diabetes diagnosis.

Interpretation: Spousal diabetes status with uncontrolled HbA1c level is an independent risk factor of individual diabetes, but strict management of spouse's HbA1c level and improving ICVHM profiles can prevent adverse effects of spousal diabetes status on diabetes risk.

Funding: National Natural Science Foundation of China (82070880, 81500660, 81870560, 81970728, 82022011, 81941017, 81970706), the Shanghai Municipal Government (18411951800), the Shanghai Shen Kang Hospital Development Center (SHDC12019101, SHDC2020CR1001A, SHDC2020CR3064B), the Program for Professor of Special Appointment (Younger Eastern Scholar) at Shanghai Institutions of Higher Learning (No.QD2016007), Innovative research team of high-level local universities in Shanghai, and the Shanghai Municipal Education Commission–Gaofeng Clinical Medicine Grant Support (20161307 and 20152508 Round 2), Shanghai Clinical Research Center for Metabolic Disease (19MC1910100).

Declaration of Interests: The authors declare that they have no competing interests.

Ethics Approval Statement: The study protocol and informed consent were approved by the Committee on Human Research at Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. All participants signed the written informed consent.

Keywords: Spouses, diabetes, previously diagnosed, uncontrolled, Ideal Cardiovascular Health Metrics

Suggested Citation

Zhao, Zhiyun and Cao, Qiuyu and Lin, Hong and Gao, Zhengnan and Xu, Min and Xu, Yu and Wang, Tiange and Li, Mian and Chen, Yuhong and Wang, Shuangyuan and Zeng, Tianshu and Hu, Ruying and Yu, Xue-Feng and Chen, Gang and Su, Qing and Mu, Yiming and Chen, Lulu and Tang, Xulei and Yan, Li and Qin, Guijun and Wan, Qin and Wang, Guixia and Shen, Feixia and Luo, Zuojie and Qin, Yingfen and Chen, Li and Huo, Yanan and Li, Qiang and Ye, Zhen and Zhang, Yinfei and Liu, Chao and Wang, Youmin and Wu, Shengli and Yang, Tao and Deng, Huacong and Zhao, Jiajun and Shi, Lixin and Ning, Guang and Lu, Jieli and Wang, Weiqing and bi, yufang, The Impact of Spousal Diabetes Status and Ideal Cardiovascular Health Metrics on Risk of Incident Diabetes: A Nationwide Prospective Cohort Study. Available at SSRN: https://ssrn.com/abstract=4307639 or http://dx.doi.org/10.2139/ssrn.4307639

Zhiyun Zhao

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases ( email )

Qiuyu Cao

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases ( email )

Hong Lin

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases ( email )

Zhengnan Gao

Dalian University of Technology - Department of Endocrinology ( email )

Dalian University - Dalian Municipal Central Hospital ( email )

Dalian
China

Min Xu

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases ( email )

Yu Xu

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases ( email )

Tiange Wang

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases ( email )

Mian Li

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases ( email )

Yuhong Chen

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases

Shuangyuan Wang

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases ( email )

Tianshu Zeng

Huazhong University of Science and Technology - Tongji Medical College ( email )

Ruying Hu

Zhejiang Provincial Center for Disease Control and Prevention - Department of Non-Communicable Disease Control and Prevention ( email )

Hangzhou
China

Xue-Feng Yu

Huazhong University of Science and Technology - Tongji Medical College ( email )

Gang Chen

Fujian Medical University - Department of Endocrinology ( email )

China
+86-1350933707 (Phone)

Fujian Academy of Medical Sciences - Fujian Provincial Key Laboratory of Medical Analysis

China

Qing Su

Shanghai Jiao Tong University (SJTU) - Xinhua Hospital ( email )

Yiming Mu

Government of the People's Republic of China - Department of Endocrinology ( email )

Lulu Chen

Huazhong University of Science and Technology - Tongji Medical College ( email )

Xulei Tang

Lanzhou University - First Hospital ( email )

Li Yan

Sun Yat-Sen University (SYSU) - Department of Endocrinology ( email )

Guangzhou, Guangdong 510120
China

Guijun Qin

Zhengzhou University - Division of Endocrinology ( email )

Qin Wan

Southwest Medical University - Affiliated Hospital ( email )

Guixia Wang

Jilin University (JLU) - Department of Endocrinology and Metabolism ( email )

China

Feixia Shen

Wenzhou Medical University - First Affiliated Hospital ( email )

Zuojie Luo

Guangxi Medical University - First Affiliated Hospital ( email )

Yingfen Qin

Guangxi Medical University ( email )

22 Shuangyong Rd
Qingxiu Qu, Nanning Shi
Guangxi Zhuangzuzizhiqu, 530021
China

Li Chen

Shandong University - Department of Endocrinology ( email )

Yanan Huo

Nanchang University - Jiangxi Provincial People’s Hospital ( email )

Qiang Li

Harbin Medical University - Second Affiliated Hospital ( email )

Zhen Ye

Zhejiang Provincial Center for Disease Control and Prevention ( email )

Binjiang
Hangzhou, 310051
China

Yinfei Zhang

Central Hospital of Shanghai Jiading District ( email )

Shanghai
China

Chao Liu

Jiangsu Province Hospital on Integration of Chinese and Western Medicine ( email )

Nanjing
China

Youmin Wang

Anhui Medical University - First Affiliated Hospital ( email )

Shengli Wu

Karamay Municipal People's Hospital ( email )

Tao Yang

Nanjing Medical University - First Affiliated Hospital ( email )

Huacong Deng

Chongqing Medical University - First Affiliated Hospital ( email )

Chongqing
China

Jiajun Zhao

Shandong First Medical University - Science and Technology Innovation Center ( email )

Jinan, Shandong
China

Shandong First Medical University - Department of Endocrinology and Metabolism ( email )

China

Shandong Academy of Clinical Medicine - Institute of Endocrinology ( email )

China

Shandong Clinical Medical Center of Endocrinology and Metabolism ( email )

China

Lixin Shi

Affiliated Hospital of Guiyang Medical College ( email )

Guang Ning

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases ( email )

Jieli Lu

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases ( email )

Weiqing Wang

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases ( email )

Yufang Bi (Contact Author)

Shanghai Jiao Tong University (SJTU) - Department of Endocrine and Metabolic Diseases ( email )

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