Design and Fabrication of High-Performance Self-Setting Trimagnesium Phosphate

Abstract

Owing to the advantages of fast-setting and high early strength, magnesium phosphate bone cement has been widely used. However, developing magnesium phosphate cement with applicable injectability, high strength and biocompatibility remains a great challenge. Herein, we propose a strategy to achieve high performance bone cement and establish a trimagnesium phosphate cement (TMPC) system. The TMPC shows the properties of high early strength, low curing temperature, netural pH, and excellent injectability, addressing the critical limitations with recently studied magnesium phosphate cement. By monitoring the hydration pH value and electroconductivity, we demonstrate that the magnesium to phosphate ratio could manipulate types and components of hydration products and their transformation by adjusting the pH of the system and influence the hydration speed. Further it could regulate the hydration network and the properties of TMPC. Moreover, in vitro study demonstrates TMPC has out-standing biocompatibility and bone filling capacity. The facile preparation properties and these advantages of TMPC demonstrate its potential as the clinic alternative to polymethylmethacrylate and calcium phosphate bone cement. This study will help rational design of high-performance bone cement.

Keywords: bone cement, magnesium phosphate cement, bioactive materials