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Definitive SARS-CoV-2 Infection & COVID-19 Vaccination in Movement Disorder Patients in Ethiopia

25 Pages Posted: 1 Feb 2023 Publication Status: Preprint

See all articles by Biniyam A. Ayele

Biniyam A. Ayele

Addis Ababa University

Abenet Tafesse

Addis Ababa University

Hanna Demissie

Addis Ababa University

Fikru Tsehayneh

Addis Ababa University

Yohannes Debebe Gelan

Addis Ababa University

Dereje Melka

Addis Ababa University

Abdi Bati Wotiye

All Africa Leprosy and Tuberculosis Rehabilitation and Training Center (ALERT Center) Hospital

Hanna A. Negash

Addis Ababa University

Abhilasha Boruah

Columbia University - Irving Medical Center

Yared Mamushet Yifru

Addis Ababa University

Ali Shalash

Ain Shams University - Department of Neurology

Wondwossen Amogne

Addis Ababa University - Department of Internal Medicine

Kiran T. Thakur

Department of Neurology - Columbia University Irving Medical Center

Abstract

Background: The magnitude of the SARS-COV-2 infection and COVID 19 vaccine uptake in patients with neurological disorders such as movement disorders (MD) including Parkinson’s disease is largely unknown in Ethiopia. There is urgency in understanding the burden of COVID-19 infection and vaccination uptake and associated factors in African patients with MD.

Method: An observational cross sectional facility based study was conducted at Tikur Anbessa Specialized Hospital (TASH) in Addis Ababa, Ethiopia. Convenient sampling technique was used and the study was conducted between March 01, 2022 and April 30, 2022. Both descriptive and inferential statistics were used.

Results: A total of 179 patients with movement disorders were included for the analysis. The median age was 62.0 (IQR 50 – 70) years. Males accounted for 62.6%. The median duration of illness was 5.0 (IQR 2 – 10) years. The commonest MD was Parkinson’s disease (61.4%) followed by essential tremor, ataxia syndromes, and dystonia syndromes respectively.  Hypertension was the most common comorbid disorder, followed by other comorbid neurological disorders and diabetes mellitus. Five (2.8%) patients have HIV infection. The infection rate of definitive SARS-COV-2 was 9.5%. COVID 19 vaccine uptake was 46.9%. Hyperkinetic MD was associated with COVID-19 infection when adjusted for age, gender, economic status, and duration of MD diagnosis (AOR 3.53 95% CI 1.14 – 10.87 p=0.03). Comorbid hypertension was positively associated with COVID vaccination (AOR 2.04 95% CI 1.01 – 14.13 p=0.04). However, lower educational status was associated with COVID vaccine hesitancy (COR 0.48 95% CI 0.25 – 0.89 p=0.02).

Conclusion: The present study shows high burden of definitive SARS-COV-2 infection and low COVID vaccine uptake in movement disorders patients attending TASH. Hyperkinetic MD was associated SARS-COV-2 infection. Lower educational level was independent predictor of low vaccine uptake.

Note:
Funding Information: None.

Declaration of Interests: All the authors have declared no conflict of interest.

Ethics Approval Statement: The study received ethical approval from Addis Ababa University, College of Health Science Ethical Clearance Committee (Protocol number: 117/19/Neuro). Informed consent has been obtained from all the participants.

Keywords: movement disorders, Parkinson's disease, SARS-COV-2, Covid 19 Vaccine, vaccine hesitancy, Ethiopia

Suggested Citation

Ayele, Biniyam A. and Tafesse, Abenet and Demissie, Hanna and Tsehayneh, Fikru and Gelan, Yohannes Debebe and Melka, Dereje and Wotiye, Abdi Bati and Negash, Hanna A. and Boruah, Abhilasha and Yifru, Yared Mamushet and Shalash, Ali and Amogne, Wondwossen and Thakur, Kiran T., Definitive SARS-CoV-2 Infection & COVID-19 Vaccination in Movement Disorder Patients in Ethiopia. Available at SSRN: https://ssrn.com/abstract=4339965 or http://dx.doi.org/10.2139/ssrn.4339965

Biniyam A. Ayele (Contact Author)

Addis Ababa University ( email )

Abenet Tafesse

Addis Ababa University ( email )

Hanna Demissie

Addis Ababa University ( email )

Fikru Tsehayneh

Addis Ababa University ( email )

Yohannes Debebe Gelan

Addis Ababa University ( email )

Dereje Melka

Addis Ababa University ( email )

Abdi Bati Wotiye

All Africa Leprosy and Tuberculosis Rehabilitation and Training Center (ALERT Center) Hospital ( email )

Hanna A. Negash

Addis Ababa University ( email )

Abhilasha Boruah

Columbia University - Irving Medical Center ( email )

622 W 168th St
New York, NY 10032
United States

Yared Mamushet Yifru

Addis Ababa University ( email )

Ali Shalash

Ain Shams University - Department of Neurology ( email )

Cairo
Egypt

Wondwossen Amogne

Addis Ababa University - Department of Internal Medicine ( email )

Kiran T. Thakur

Department of Neurology - Columbia University Irving Medical Center ( email )

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