High-Sensitivity, Real-Time Healthcare Monitoring Platform with Solution-Processed Ultrathin Metal Oxide Electrolyte-Gated Transistors

Abstract

The need for rapid, non-invasive detection of bio-signals has been increasing, and its platform has been requiring high sensitivity, selectivity, and strong chemical resistance for the detection of biomolecules in a physiological environment. Herein, we propose solution-processed, ultrathin, gallium-doped, indium oxide (GIO) semiconductor-based electrolyte-gated transistors (EGTs) and their patchable and real-time healthcare monitoring platforms. GIO EGTs have higher electrical stability than non-doped indium oxide EGTs, and this possibly could be attributed to the reduction of the oxygen deficiency regarding the interface defects between the electrolyte and the surface of the semiconductor. The sensitivity of GIO EGTs reached a maximum value of 78 mV pH−1, exceeding the Nernst limit of 59 mV pH−1. Thus, we were able to fabricate flexible, patchable GIO EGT-based biosensors with a wireless, communication-based, electrical acquisition system and visualization of data in real-time monitoring.

Keywords: Biosensors, real-time monitoring, electrolyte-gated transistor, thin film, solution process