Correlations of Kratom (Mitragyna Speciosa Korth.) Tea Bag Preparations and Reported Pharmacological Effects

Abstract

Ethnopharmacological relevance: The use of herbal tea infusions is widespread in ethnomedicine throughout the world. One such ethnobotanical is kratom (Mitragyna speciosa Korth., Rubiaceae) which has gained considerable interest as an herbal supplement in recent years in the West beyond its native Southeast Asia. Traditional, kratom leaves are either chewed fresh or made into a tea infusion to treat fatigue, pain, or diarrhea. However, dried kratom leaf powder and hydroalcoholic extracts are more commonly used in Western countries, raising the question of exposure to kratom alkaloids and related effects.

Aim of the study: A specific kratom tea bag product was analyzed for mitragynine content using tea infusion preparation and methanolic extraction. Consumers of both the tea bag product and other kratom products completed an online anonymous survey to determine demographics, kratom use patterns, and self-reported beneficial and detrimental effects.

Materials and Methods: Kratom tea bag samples were extracted using pH-adjusted water or methanol and analyzed using an established LC-QTOF method. A modified kratom survey was distributed to consumers of the kratom tea bag products and other kratom products over a 14-month period.

Results: Tea infusion extraction of tea bag samples resulted in lower mitragynine levels (0.062-0131 %(w/w)) compared to methanolic extraction (0.485-0.616% (w/w)). Kratom tea bag consumers did report similar, although often milder beneficial effects compared to consumers using other kratom products. Overall self-reported health was better among kratom tea bag consumers whereas improvement of a diagnosed medical condition was less in tea bag consumers compared to those using other kratom products.

Conclusions: Traditional tea infusions of Mitragyna speciosa dried leaves provide benefits to consumers despite substantially lower mitragynine content. These effects may be less pronounced but indicate that tea infusions provide a potentially safer formulation compared to more concentrated products.

Note:
Funding declaration: This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

Conflict of Interests: Oliver Grundmann declares that he is a member of the Advisory board for the American Kratom Vendors Association. The Authors declare that there is no conflict of interest.

Ethical Approval: All study procedures were approved by the Institutional Review Board at the University of Florida (IRB # 2021-00874).

Keywords: Kratom, mitragynine, tea infusion, Mitragyna speciosa