Acetabular Dysplasia and the Risk of Developing Hip Osteoarthritis at 2,5,8, and 10 Years Follow-Up in a Prospective Nationwide Cohort Study (CHECK)

21 Pages Posted: 13 Mar 2023

See all articles by Noortje Sophie Riedstra

Noortje Sophie Riedstra

Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC)

Rebecka Vinge

Lund University

Julie Herfkens

Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC)

Denise Eygendaal

Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC)

Sita M.A. Bierma-Zeinstra

Erasmus University Rotterdam (EUR) - Department of General Practice

Jos Runhaar

Erasmus University Rotterdam (EUR) - Department of General Practice

Michiel M.A. van Buuren

Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC)

Rintje Agricola

Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC)

Abstract

Objective: To assess the relationship between acetabular dysplasia (AD) and the risk of incident and end-stage radiographic hip osteoarthritis (RHOA) over 2,5,8 and 10 years.

Design: Individuals (n=1002) aged between 45-65 from the prospective Cohort Hip and Cohort Knee (CHECK) were studied. Anteroposterior pelvic radiographs were obtained at baseline and 2,5,8, and 10-years follow-up. False profile radiographs were obtained at baseline. AD was defined as a lateral center edge angle, an anterior center edge angle, or both <25° at baseline. The risk of developing RHOA was determined at each follow-up moment. Incident RHOA was defined by Kellgren & Lawrence (KL) grade ≥2 or total hip replacement (THR), end-stage RHOA by a KL grade ≥3 or THR. Associations were expressed in odds ratios (OR) using logistic regression with generalized estimating equations.

Results: AD was associated with the development of incident RHOA at 2 years follow-up (OR 2.46, 95% CI 1.00–6.04), 5 years follow-up (OR 2.28, 95% CI 1.20-4.31), and 8 years follow-up (OR 1.86, 95%CI 1.22-2.83). AD was only associated with end-stage RHOA at 5 years follow-up (OR 3.75, 95% CI 1.02-13.77). No statistically significant associations were observed between AD and RHOA at 10-years follow-up.

Conclusion: Baseline AD in individuals between 45-65 years is associated with an increased risk of developing RHOA within 2- and 5 years. However, this association seems to weaken after 8 years and disappears after 10 years.

Note:
Funding declaration: The CHECK cohort was funded by the Dutch Arthritis Society, but there was no funding for the present study.

Conflicts of Interest: None

Ethical Approval: Written informed consent was obtained from all participants, and the study was approved by the medical ethical committee of each hospital.

Suggested Citation

Riedstra, Noortje Sophie and Vinge, Rebecka and Herfkens, Julie and Eygendaal, Denise and Bierma-Zeinstra, Sita M.A. and Runhaar, Jos and van Buuren, Michiel M.A. and Agricola, Rintje, Acetabular Dysplasia and the Risk of Developing Hip Osteoarthritis at 2,5,8, and 10 Years Follow-Up in a Prospective Nationwide Cohort Study (CHECK). Available at SSRN: https://ssrn.com/abstract=4369529 or http://dx.doi.org/10.2139/ssrn.4369529

Noortje Sophie Riedstra (Contact Author)

Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC) ( email )

Rebecka Vinge

Lund University ( email )

Julie Herfkens

Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC) ( email )

Denise Eygendaal

Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC) ( email )

Sita M.A. Bierma-Zeinstra

Erasmus University Rotterdam (EUR) - Department of General Practice ( email )

Jos Runhaar

Erasmus University Rotterdam (EUR) - Department of General Practice ( email )

Michiel M.A. Van Buuren

Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC) ( email )

Rintje Agricola

Erasmus University Rotterdam (EUR) - Erasmus Medical Center (MC) ( email )

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