Manganese-Catalyzed Deoxygenation of Secondary and Tertiary Amides Under Mild Reductions

Abstract

Herein, we report the deoxygenation of secondary and tertiary amides enabled by [Mn(CO)5Br] with Ph2SiH2 or inexpensive polymethylhydrosiloxane (PMHS) as the reducing agent, which provides expedient access to the corresponding secondary and tertiary amines. The operationally simple transformation proceeds under mild conditions without external ligands, as well as features high catalytic efficacy and good functional-group tolerance. Furthermore, the generality of this developed catalytic system was further demonstrated by the late-stage modification of bioactive molecules.

Keywords: manganese, deoxygenation, amides, silane, amines