Dual-Template Induced Interfacial Assembly of Yolk-Shell Magnetic Mesoporous Polydopamine Vesicles with Tunable Cavity For Enhanced Photothermal Antibacterial

Abstract

Yolk-shell magnetic polymer nanostructures with large cavity, movable magnetic core are attractive carriers for bulk storage, release and transport of guest molecules in various applications. However, it remains great challenge to achieve a controllable transport of guest species into and out from the hollow space in a controlled way due to the lack of tailor-made nanostructures. Herein, a dual-template-induced emulsion interfacial assembly and polymerization method (denoted as de-IAP) was developed to construct yolk-shell magnetic mesoporous polydopamine (YS-MMP) vesicles with magnetic core, large hollow space and uniform mesopores in the soft polymer shell. The obtained YS-MMP vesicles possess tunable cavity size (10-900 nm), flexible mesoporous PDA layer, large pores (21 nm), high surface area (217.4 m2·g-1) and high magnetization saturation (31.0 emu·g-1), thus exhibiting the merits of high loading capacity (29.1%) and encapsulation rates (41.0%) of Curcumin (Cur), and fast magnetic separation speed. Thanks to their superior photothermal effect and magnetic property, the obtained YS-MMP@Cur vesicles exhibit smart on-demand release of Cur and excellent recyclability. With 808 nm laser irradiation, YS-MMP@Cur vesicles show high-efficient photothermal bactericidal effect (> 99%) against S. aureus and E. coli, opening up a new avenue for smart cargo delivery, lasting sterilization, and environmental remediation.

Keywords: Yolk-shell, Mesoporous polydopamine, Interface coassembly, Smart drug release, Photothermal antibacterial