Peripheral Arterial Disease in Women: The Effects of Smoking and Environmental Tobacco Smoke

18 Pages Posted: 31 Oct 2023

See all articles by Faith Shaw

Faith Shaw

Howard University - College of Medicine

Rhema Johnson

Georgetown University

Richard Gillum

Howard University

David Johnson

Howard University

Kakra Hughes

Howard University

Date Written: April 15, 2023

Abstract

Peripheral arterial disease (PAD) is an arteriosclerotic disease of the extremities that affects 8 to 12 million individuals in the United States. Reports on women are few. The hypothesis was tested that PAD prevalence was significantly higher among those exposed to environmental tobacco smoke (ETS) than in unexposed. Data from the National Health and Nutrition Examination Survey (NHANES) from 1999-2002 and 2003-2004 were used. PAD was defined as ankle brachial index (ABI) ≤ 0.90 in either leg. Serum cotinine levels were measured. All analyses took the complex survey design and weights into account. Among 4,075 women aged 40 years and older with complete data, multiple logistic regression analysis showed that light and heavy smoking cotinine categories but not ETS were associated with adjusted odds ratios > 1.0 for PAD (Figure 1). No association appeared for ETS in age or race subgroups. In a national survey of women, ETS exposure was not associated with prevalence of PAD overall or in subgroups of age and race.

Note:
Funding Information: There was no source of funding for this research.

Conflict of Interests: The authors have no competing interests to declare.

Keywords: peripheral vascular disease, ankle-brachial index, secondhand smoke, atherosclerosis

Suggested Citation

Shaw, Faith and Johnson, Rhema and Gillum, Richard and Johnson, David and Hughes, Kakra, Peripheral Arterial Disease in Women: The Effects of Smoking and Environmental Tobacco Smoke (April 15, 2023). Available at SSRN: https://ssrn.com/abstract=4421184 or http://dx.doi.org/10.2139/ssrn.4421184

Faith Shaw (Contact Author)

Howard University - College of Medicine ( email )

520 W St NW
Washington, DC 20059
United States

Rhema Johnson

Georgetown University

Richard Gillum

Howard University ( email )

2900 Van Ness Street, N.W.
Washington, DC 20008
United States

David Johnson

Howard University

Kakra Hughes

Howard University

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