Biosynthesis of Cyclic Ketones by a H2o2 Self-Sufficient Cascade Reaction

Wu, Bin; Wang, Xiangyun; Yang, Bo; Ma, Yunjian; Hollmann, Frank; Wang, Yonghua

doi:10.2139/ssrn.4429343

Download This Paper

Open PDF in Browser

Add Paper to My Library

Biosynthesis of Cyclic Ketones by a H2o2 Self-Sufficient Cascade Reaction

16 Pages Posted: 25 Apr 2023

See all articles by Bin Wu

In the present work we propose a bienzymatic cascade for the oxyfunctionalisation of cycloalkanes to cyclic alcohols/cyclic ketones. By combining a H2O2-dependent peroxygenase with a O2-consuming and H2O2-producing alcohol oxidase an overall aerobic oxidation system was established. A convincing proof-of-concept is presented and some current limitations are outlined.

Keywords: Cyclohexanone, Alcohol oxidase, unspecific peroxygenase, H2O2 self-cycling

Suggested Citation: Suggested Citation

Wu, Bin and Wang, Xiangyun and Yang, Bo and Ma, Yunjian and Hollmann, Frank and Wang, Yonghua, Biosynthesis of Cyclic Ketones by a H2o2 Self-Sufficient Cascade Reaction. Available at SSRN: https://ssrn.com/abstract=4429343 or http://dx.doi.org/10.2139/ssrn.4429343