Bioinspired Poly(Aspartic Acid) Based Hydrogel with ROS Scavenging Ability as MEGF Carrier for Wound Repairing Applications

Abstract

Poly(amino acid) based self-healing hydrogels have important application in biomedications. In this research, the catechol pendant groups were imported to poly(aspartic acid) based self-healing hydrogel to improved skin adhesion and ROS scavenging performance. The poly(succinimide) (PSI) was reacted with 3,4-dihydroxyphenylalanine (DA) and then hydraziolyzed to import catechol group and hydrazide group respectively, which are responsible for mussel inspired tissue adhesion and dynamic coupling reactivity. The dopamine modified poly(aspartic hydrazide) (PDAH) was reacted with PEO90 dialdehyde (PEO90 DA) to prepare hydrogels, and the resultant hydrogel showed good biocompatibility both in vitro and in vivo. The skin adhesion strength of the mussel inspired hydrogel increased notably with enhanced radical scavenging efficiency fit in vivo wound repairing applications. The PDAH/PEO90 DA hydrogel also showed sustained albumin release profile and the in vivo wound repairing experiment proved the mEGF loaded hydrogel as wound dressing material accelerated the wound repairing rate.

Note:
Funding declaration: This work was supported by the National Natural Science Foundation of China (82072327) and Medical Science Foundation of Hebei University (2021A01, 2021X01).

Conflict of Interests: The authors declare that they have no conflict of interest.

Ethical Approval: Our animal experiment was approved by Animal Welfare and Ethical Committee of Hebei University (Approval No. IACUC-2021XS022).

Keywords: poly(aspartic acid), self-healing hydrogel, skin adhesion, hemostasis, wound repairing