Immune Response Against COVID-19 in a Population Aged 18 Years and Above, in 2022, Cali, Colombia

16 Pages Posted: 27 May 2023

See all articles by Maryory Galvis Pedraza

Maryory Galvis Pedraza

University of Groningen; Universidad Libre Cali; Secretaria de Salud Distrital Cali

Angelica Murica-Viveros

Universidad Libre Cali

Armando Lumumi-Moreno

Universidad Libre Cali

Robinson Pacheco

Universidad Libre Cali

Carlos A. Reina

Universidad de Antioquia

Germán Ávila

Secretaría de Salud Distrital Cali

Pablo Roa

Secretaría de Salud Distrital Cali

Miyerlandi Torres

Secretaría de Salud Distrital Cali

Date Written: May 21, 2023

Abstract

Background and Objective: Immunization is a protective measure against COVID‐19. This research aimed to estimate the association of protective levels of total IgG anti-S antibodies to SARS-CoV2 induced by vaccination and clinical and sociodemographic characteristics in a population of Cali, December 2021-February 2022.

Study Design and Setting: A cross-sectional analytical study; 394 participants over 18 years with complete vaccination against COVID-19 were included. The antibodies were done by ELISA Immunoassay test. Multivariate analysis and logistic regression models were applied.

Results: Protective antibody titers (≥ 1000 (BAU/mL) were reached by 282 participants. The variables associated were a) Type of vaccine aOR 2,40 (95% CI [0.99-5,84]) (p <0,053) for mRNA, against Inactivated viral vector vaccines users. b) Heterologous vaccination aOR 2.39 (95% CI [1.14-5.02]) (p < 0.021) and c) Time 21 days and more since the booster dose, aOR 2.62 (95% CI [1.29-5.30]) (p < 0.007), symptoms related to COVID-19 and age were not significant.

Conclusions: The heterologous vaccination and the time after the last dose are important variables to predict the achievement of protective levels of antibodies against COVID-19, providing information to evaluate the performance of the immunization in Cali and highlighting these variables for future analysis.

Note:
Funding Information: This research was financed by the Secretaria de Salud Distrital de Santiago de Cali and the Universidad Libre Seccional Cali.

Conflict of Interests: The authors declare that they have no conflicts of interest that could influence the results or conclusions of the article.

Ethical Approval: This research was approved and classified under risk-free research by the research ethics and bioethics committee of the Faculty of Health Sciences of the Universidad Libre - Colombia according to act No. CEB-013-2021 of December 12, 2021.

Keywords: SARS-CoV-2, ELISA, COVID-19, vaccine, antibody

JEL Classification: I1

Suggested Citation

Galvis Pedraza, Maryory and Murcia Viveros, Angelica and Lumumi Moreno, Armando and Pacheco López, Robinson and Reina, Carlos Alberto and Ávila, Germán and Roa, Pablo and Torres, Miyerlandi, Immune Response Against COVID-19 in a Population Aged 18 Years and Above, in 2022, Cali, Colombia (May 21, 2023). Available at SSRN: https://ssrn.com/abstract=4454595 or http://dx.doi.org/10.2139/ssrn.4454595

Maryory Galvis Pedraza (Contact Author)

University of Groningen ( email )

P.O. Box 800
9700 AH Groningen, Groningen 9700 AV
Netherlands
0627562924 (Phone)
8921 ED (Fax)

Universidad Libre Cali ( email )

Diagonal 37A Nro. 3 - 29
Santa Isabel PBX
Cali, 472
Colombia
0627562924 (Phone)
8921 ED (Fax)

Secretaria de Salud Distrital Cali ( email )

Cl. 4b #36-00, El Sindicato, Cali, Valle del Cauca
Cali, 760001
Colombia
0627562924 (Phone)
8921 ED (Fax)

Angelica Murcia Viveros

Universidad Libre Cali

Armando Lumumi Moreno

Universidad Libre Cali

Robinson Pacheco López

Universidad Libre Cali

Carlos Alberto Reina

Universidad de Antioquia

Germán Ávila

Secretaría de Salud Distrital Cali

Pablo Roa

Secretaría de Salud Distrital Cali

Miyerlandi Torres

Secretaría de Salud Distrital Cali

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