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Physical Activity, Sedentary Behavior, Sleep and Risk of Incident Parkinson's Disease: A Prospective Cohort Study of 401,697 Participants
37 Pages Posted: 22 Jun 2023
More...Abstract
Background: The effects of physical activity (PA), sedentary behavior (SB), and sleep duration on developing Parkinson’s disease (PD) are inconsistent. This study aimed to examine the independent and joint associations of PA, SB, sleep with PD risk.
Methods: A total of 401,697 participants without PD were included in the analyses from UK Biobank with a median follow-up of 7·7 years. Cox proportional hazards regression models were used to estimate the association of three modifiable behaviors, individually and jointly, with PD risk. Models fitted with restricted cubic spline were conducted to test for linear and nonlinear shapes of each association
Findings: Our analytic sample included 401,697 participants with 3030 identified cases of PD (mean age, 58 years; 62·9% male). PD risk was 14% higher in the high sleep group (95% CI, 1·05-1·24), 18% lower in the high TPA group (0·75-0·91), and 22% lower in the high LTPA group (0·71-0·86) compared with the low group, respectively. Total SB time was irrelevant with PD risk, while high TV viewing showed an increased risk of PD compared to the low group (HR [95%CI]: 1·12 [1·02-1·22]). Low computer use (0h/day) was associated with higher PD risk compared to the moderate group (1h/day) (1·14 [1·04, 1·26]). A combination of 7h/day sleep, moderate-to-high computer use, and moderate-to-vigorous intensity of LTPA showed lower PD risk (0·74 [0·62-0·88]).
Interpretation: PA, SB, and sleep were independently associated with PD risk. Reduced risk of PD was expected with combinatorial changes in lifestyle behaviors, suggesting better lifestyle for PD prevention.
Funding: Science and Technology Innovation 2030 Major Projects, National Key R&D Program of China, National Natural Science Foundation of China, Shanghai Municipal Science and Technology Major Project, Research Start-up Fund of Huashan Hospital, Excellence 2025 Talent Cultivation Program at Fudan University, Shanghai Rising-Star Program.
Declaration of Interest: The authors declare no competing interests.
Ethical Approval: All participants gave written informed consent prior data collection. UK Biobank has full ethical approval from the NHS National Research Ethics Service. Analyses were conducted under application number 19542. This research conforms to the Declaration of Helsinki.
Keywords: Exercise, Physical activity, Epidemiology, Sleep, Parkinson's disease, Sedentary Behaviors
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