Comparative Analysis of Different Measles Vaccine-Associated Rash Illnesses in Shandong Province, China,2014-2021

27 Pages Posted: 24 Aug 2023

See all articles by Suting Wang

Suting Wang

Shandong Center for Disease Control and Prevention

Xueqiang Fang

Maternal and Child Health Care Hospital of Shandong Province

Xiaodong Liu

Shandong Center for Disease Control and Prevention

Yao Liu

Shandong Center for Disease Control and Prevention

Ping Xiong

Shandong Center for Disease Control and Prevention

Zexin Tao

Shandong Center for Disease Control and Prevention

Qing Xu

Anhui Provincial Center for Disease Control and Prevention

Meng Chen

Shandong Center for Disease Control and Prevention

Li Zhang

Shandong Center for Disease Control and Prevention

Aiqiang Xu

Shandong Center for Disease Control and Prevention

Abstract

Measles vaccine-associated rash illness (VARI) cases were detected along with measles case-based surveillance in Shandong province, china. Here we compared characteristics of 156 VARI cases, conformed by the WHO criteria only without available genotype and genotype A cases. Meanwhile the genetic analysis of genotype A were conducted. Our result reveal 90.38% of 156 VARIs were the children aged 8 months to 18 months who had received one dose of measles-containing vaccine, which was 100% in genotype A cases. However, incidence of clinical complications in genotype A cases was much higher than that in VARIs. Statistic analysis verified the linear correlation of measles morbidity with incidence VARIs, but not with the incidence of genotype A cases. The nucleotide identities of Shandong genotype A sequence was 99.7% -100%. 90.91% sequences (30/33) were totally as the same as the Shanghai-191. Two nucleotide mutation (G1183A and T1307G) were found, introducing amino acid mutation S291N and L339V. The evolutionary rate calculated by Bayesian MCMC method was 1.6×10-4 substitutions/site/year (95%HPDS: 1.049×10-6~4.98×10-4). Selective pressure analysis suggested all the codon sites were conservative(ω=0.845). According to our study, the incidence of VARI may be influenced by high incidence of measles, so it is necessary to improve the identification of genotype to avoiding the misjudgment of VARIs. Although the nucleotide of genotype A were conservative, mutation were still found. So it is necessary to supervise the measles vaccine-associated rash illnesses.

Note:
Funding declaration: This study was supported by a grant from Medical and Health Science and Technology Development Plan Program of Shandong (202012051 -301), Taishan Scholar Program of Shandong Province (Tstp20221164) and a grant from Taishan Scholar Program of Young Experts (tsqn.202103187).

Conflict of Interests: All authors declare no competing interests.

Ethical Approval: This study was approved by IRB for Preventive Medicine of Shandong Center for Disease Control and Prevention under ethics approval no. 2021-6, and the methods were performed in accordance with the approved guidelines.

Keywords: Measles virus, Vaccine-associated rash illness, Genotype A

Suggested Citation

Wang, Suting and Fang, Xueqiang and Liu, Xiaodong and Liu, Yao and Xiong, Ping and Tao, Zexin and Xu, Qing and Chen, Meng and Zhang, Li and Xu, Aiqiang, Comparative Analysis of Different Measles Vaccine-Associated Rash Illnesses in Shandong Province, China,2014-2021. Available at SSRN: https://ssrn.com/abstract=4543381 or http://dx.doi.org/10.2139/ssrn.4543381

Suting Wang (Contact Author)

Shandong Center for Disease Control and Prevention ( email )

China

Xueqiang Fang

Maternal and Child Health Care Hospital of Shandong Province ( email )

Xiaodong Liu

Shandong Center for Disease Control and Prevention ( email )

China

Yao Liu

Shandong Center for Disease Control and Prevention ( email )

China

Ping Xiong

Shandong Center for Disease Control and Prevention ( email )

China

Zexin Tao

Shandong Center for Disease Control and Prevention ( email )

China

Qing Xu

Anhui Provincial Center for Disease Control and Prevention ( email )

Meng Chen

Shandong Center for Disease Control and Prevention ( email )

China

Li Zhang

Shandong Center for Disease Control and Prevention ( email )

China

Aiqiang Xu

Shandong Center for Disease Control and Prevention ( email )

China

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