The Effect of Biological-Mineral Scaffold (HA-Decellularized Pericardium) in Skull Bone Defect of Rat: A Comparative Evaluation between Bovine and Camel

Abstract

The emergence of bone tissue engineering as a promising approach to repair bone defects using artificial bone scaffolds made of biomaterials and additives has been introduced. The study highlights the potential of a new hydroxyapatite collagen-based scaffold for bone tissue engineering with a new insight on bovine and camel xenografts. In-vitro and in-vivo comparisons were carried out to evaluate the potential of a biological-mineral scaffold composed of hydroxyapatite-decellularized pericardium for treating skull bone defects in rats. Both bovine and camel pericardium scaffolds exhibited biocompatibility in-vivo, but the study showed that pericardium scaffold is a better xenograft than camel pericardium for tissue engineering in bone tissue repair. The results provide valuable insights for the future development of scaffold-based tissue engineering strategies for bone regeneration, with implications for clinical translation.

Note:
Funding declaration: This research was supported financially by Semnan University of Medical Sciences (grant no. A-10-503-6).

Conflict of Interests: The authors declare no conflict of interests.

Ethical Approval: This study was approved by the Research Ethics Committee of Semnan University Of Medical Sciences and Health Services (register number: IR.SEMUMS.REC.1399.049)

Keywords: Tissue engineering, Decellularized pericardium, Bone-regeneration, Hydroxyapatite scaffold