Gastrointestinal Symptoms Have a Non-Temporal Association with Regression in a Cohort with Autism Spectrum Disorder Using the Simons Simplex Collection

23 Pages Posted: 18 Sep 2023

See all articles by Jacob Albers

Jacob Albers

University of South Florida

Adriana Bagos-Estevez

University of South Florida

LeeAnne Green Snyder

Simons Foundation

Athanasios Tsalatsanis

University of South Florida

Amelia Boehme

Columbia University Medical Center, Department of Neurology

Jennifer M. Bain

Columbia University - Irving Medical Center

Abstract

Autism spectrum disorder (ASD) can present with developmental regression. In this study, we hypothesize an association between GI symptoms and regression. We conducted a two-part analysis using data from the Simon Simplex Collection consisting of 2,564 ASD probands. Independent sample t-tests or chi-squared tests were utilized comparing regression against no-regression groups, and regression in children with and without early onset of GI symptoms. The presence of GI symptoms of any kind is associated with regression (odds ratio= 1.51; 95% CI 1.25 - 2.82; p<0.001). Early GI effects on subsequent development of regression demonstrate no association (OR=0.81; 95% CI 0.649-1.01; p<0.062). Although a clear relationship between GI Symptoms and regression is demonstrated in this study, the lack of temporal relationship between the two highlight the need for a better understanding of the underlying mechanism behind this phenomenon.

Note:

Funding Information: None.

Conflict of Interests: There are no relevant conflicts of interest.

Keywords: Gastrointestinal, Autism, Spectrum, Regression, Loss

Suggested Citation

Albers, Jacob and Bagos-Estevez, Adriana and Snyder, LeeAnne Green and Tsalatsanis, Athanasios and Boehme, Amelia and Bain, Jennifer M., Gastrointestinal Symptoms Have a Non-Temporal Association with Regression in a Cohort with Autism Spectrum Disorder Using the Simons Simplex Collection. Available at SSRN: https://ssrn.com/abstract=4567053 or http://dx.doi.org/10.2139/ssrn.4567053

Jacob Albers

University of South Florida ( email )

Adriana Bagos-Estevez (Contact Author)

University of South Florida ( email )

LeeAnne Green Snyder

Simons Foundation ( email )

United States

Athanasios Tsalatsanis

University of South Florida ( email )

Tampa, FL 33620
United States

Amelia Boehme

Columbia University Medical Center, Department of Neurology ( email )

College of Physicians and Surgeons
630 West 168th Street, 3rd Floor, Suite 3-470
New York, NY 10032-3784
United States

Jennifer M. Bain

Columbia University - Irving Medical Center ( email )

622 W 168th St
New York, NY 10032
United States

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