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One Health Approach and Meta-Analysis for Influenza Prevention
26 Pages Posted: 19 Sep 2023
More...Abstract
Background: Influenza is a global One Health issue, and nanoparticle vaccines or drugs can be good solutions against influenza. Given their ability to distribute drugs precisely, increase efficacy, and minimize adverse effects, nanoparticles have gained attention as viable candidates for the prevention and treatment of influenza. The effectiveness, safety, and potential uses of nanoparticles in the prevention and treatment of influenza are assessed by this meta-analysis.
Methods: Studies on nanoparticle-based influenza prevention (natural compounds like curcumin) and treatment were gathered and examined using a methodical literature search. The results were evaluated.
Findings: The findings show that nanoparticles considerably enhance the effectiveness of influenza prevention. In animal models, nanoparticles show improved antiviral activity, lowering viral load and boosting survival rates. Targeted drug administration enables higher drug concentrations at the infection site to maximize therapeutic advantages. In contrast to traditional antiviral medications, nanoparticle-based therapies exhibit superior safety profiles with little cytotoxicity and fewer side effects. Additionally, the combination of phytochemicals and nanoparticles offers hope for the treatment of influenza. These bioactive substances provide durable therapy alternatives while also exhibiting natural therapeutic qualities that improve antiviral activity. New therapeutic options for antiviral agents are made possible by the combination of phytochemicals and nanoparticles.
Conclusion: In conclusion, nanoparticles have demonstrated effectiveness and safety in the treatment of influenza. They serve as effective therapeutic agents because of their targeted medication delivery and improved antiviral activities. Their potential is further increased by the addition of phytochemicals. Future studies should concentrate on developing the best nanoparticle formulations possible, comprehending how they work, and investigating combinatorial strategies. The revolutionary effect of nanoparticles in the treatment of influenza shows promise for better antiviral medicines and improved patient outcomes.
Funding: This research was funded by VtR Inc-CGU (SCRPD1L0221), DOXABIO-CGU (SCRPD1K0131), and a CGU grant (UZRPD1L0011, UZRPD1M0081).
Declaration of Interest: The authors declare that they have no competing interests.
Keywords: Meta-Analysis, One Health, Prevention, Influenza, Nanoparticles, Treatment
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