Post-Synthetic Modification of Mil-53(Fe) with Tb3+ and Guanosine Monophosphate: Construction of a Fluorescent Dual-Target Sensor

Abstract

Development of fluorescence-based multi-target sensing sensors has great potential for applications in food safety monitoring and biomedical analysis. Nevertheless, the intricate design remains a hurdle in the construction of these sensors. The luminescent metal-organic frameworks (LMOFs) are suitable materials for the construction of multi-target fluorescent sensors due to their ability to introduce multiple luminescent centers and specific reaction sites through post-synthetic modification (PSM). In this study, a dual-target fluorescent sensor was fabricated via PSM of MIL-53(Fe) with Tb3+ and guanosine monophosphate (GMP). The sensor, Tb-GMP@MIL-53(Fe), has multiple luminescent centers and specific recognition sites, successfully achieved the detection of hydrogen peroxide (H2O2) and acid phosphatase (ACP) with a limit of detection (LOD) of 0.18 μM and 0.72 U/L, respectively. Furthermore, Tb-GMP@MIL-53(Fe) shows great potential for the determination of H2O2 in milk and ACP serum. More significantly, this study demonstrates the potential of post-synthetic modified LMOFs in developing dual/multiple target fluorescent sensors, expanding the scope of sensor designs for various analytes.

Keywords: Metal-organic frameworks Post-synthetic modification Dual-target sensor Hydrogen peroxide Acid phosphatase