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Global Burden of Early Onset Ischemic Heart Diseasein Adolescents and Young Adults, 1990-2019: Systematic Analysis of the Global Burden of Disease Study 2019
30 Pages Posted: 11 Oct 2023
More...Abstract
Background and Aim: Early-onset ischemic heart disease (IHD) is an emerging burden and is associated with high morbidity and mortality. Our objective was to estimate the global incidence, prevalence, and disability-adjusted life years (DALYs) of IHD in adolescents and young adults between 1990 and 2019.
Methods: Data on the burden of early-onset IHD in adolescents and young adults (aged 15-39 years) from 1990 to 2019 were gathered from the Global Burden of Disease Study for 204 countries and territories, including prevalence, incidence, DALY, and death. Norpred analysis was used to predict the burden of IHD from 2020-2030.
Results: In 2019, early-onset IHD affected 795,600 individuals globally, with a prevalence case of 5.4 million. This resulted in the number of 12.2 million DALY and 212,216 deaths. The age-standardized incidence rate (ASIR) was increased slightly, particular in high and middle socio-demographic indices (SDI) regions. Countries with middle had the highest incidence cases of 251,400, and the high SDI regions had the highest ASIR of 31.12. The low-middle SDI countries exhibited the highest age-standardized death rate (ASDR) of 9.80 and age-standardized DALY rate of 557.08. For sex pattern, the global number of incidence cases and deaths were higher in males than in females (incidence: 473,600 vs 321,900; death 151,500 vs 60,700). The top three attributable risk factors were: high low-density lipoprotein cholesterol (LDL-C), high systolic blood pressure and particulate matter pollution. By 2030, the number of cases of early-onset IHD would increase to 850,794 cases (males 512,566, females 338,462).
Conclusions: The burden of early-onset IHD has been increasing globally over past 20 years. Specifically, low SDI countries exhibited a high death burden; middle and high SDI countries had high incidence. Men have a more substantive burden than women. High LDL-C, high systolic blood pressure, and particulate matter pollution were the primary attributors.
Funding: This work was supported by the Natural Science Foundation of China (No. 82160371 to J.Z., No.82100869 and No.82360162 to P.Y., 202201011395 to X. L); Natural Science Foundation of Guangdong (202201011395 to X. L); Basic and Applied Basic Research Project of Guangzhou (202201011395 to X.L); Natural Science Foundation in Jiangxi Province grant [20224ACB216009 to J.Z];the Jiangxi Province Thousands of Plans (No. jxsq2023201105 to P.Y); and the Hengrui Diabetes Metabolism Research Fund (No. Z-2017-26-2202-4 to P.Y).
Declaration of Interest: The authors have no relevant conflicts of interest to disclose.
Keywords: Ischemic heart disease, Global burden of disease, Adolescents, Disability-adjusted life years, Prevalence, Incidence, death, Cardiovascular diseases
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