Glucose Detection Via Photoelectrochemical Sensitivity of 3d Cuo-Tio2 Heterojunction Nanotubes/Ti Combined with Chemometric Tools

Abstract

High sensitivity and low detection limit are important targets for biosensors. Using 3D hydrogen titanate nanotubes/Ti as precursor, CuO-TiO2 heterojunction nanotubes/Ti (CuO-TiO2NTs/Ti) photoelectrode was prepared to fabricate photoelectrochemical (PEC) glucose sensor. The prominent Ti foil substrate, 3D mesoporous structure, and CuO-TiO2 heterojunction of this PEC sensor can effectively improve the separation efficiency of charge carriers, facilitate electron transfer, and generate strong photoelectronic signals. Under visible light irradiation, the CuO-TiO2NTs/Ti electrode exhibited high sensitivity, low LOD, and good selectivity. Through density functional theory simulation, the enhanced electron-hole separation and improved PEC properties were illuminated in the CuO-TiO2 heterojunction. Associated with chemometric tools, the accuracy of the sensitivity was significantly improved, which could enhance the practical application capability of PEC biosensors.

Keywords: 3D CuO-TiO2 nanotubes/Ti, Heterojunction, Photoelectrochemical sensor, Density functional theory simulation, Glucose detection, Chemometric tools