lancet-header

Preprints with The Lancet is part of SSRN´s First Look, a place where journals identify content of interest prior to publication. Authors have opted in at submission to The Lancet family of journals to post their preprints on Preprints with The Lancet. The usual SSRN checks and a Lancet-specific check for appropriateness and transparency have been applied. Preprints available here are not Lancet publications or necessarily under review with a Lancet journal. These preprints are early stage research papers that have not been peer-reviewed. The findings should not be used for clinical or public health decision making and should not be presented to a lay audience without highlighting that they are preliminary and have not been peer-reviewed. For more information on this collaboration, see the comments published in The Lancet about the trial period, and our decision to make this a permanent offering, or visit The Lancet´s FAQ page, and for any feedback please contact preprints@lancet.com.

Effect of Informational Videos on Vaccine Perceptions Among Unvaccinated Individuals: A Randomized Control Trial

29 Pages Posted: 25 Oct 2023

See all articles by Seung-Keun Martinez

Seung-Keun Martinez

University of Nottingham

Silvia Sonderegger

University of Nottingham

Andy Brownback

University of Arkansas

Guillermo Cruces

Universidad Nacional de La Plata - Centro de Estudios Distributivos, Laborales y Sociales (CEDLAS); IZA

Monika Pompeo

New York University (NYU) - New York University, Abu Dhabi

Joanne R. Morling

University of Nottingham

More...

Abstract

Background By 2022, COVID-19 vaccine uptake had plateaued. We tested whether unvaccinated individuals in 2022 were wilfully avoiding vaccine information, or if they would voluntarily accept vaccine education.

Methods In this double-blind, parallel, randomised controlled trial, we recruited US residents to participate in an online survey-experiment between January 27, 2022 and February 25, 2022. Subjects were first screened for vaccination status. Unvaccinated individuals were then separately invited into the survey. We developed video-based informational interventions that provide detailed, yet easy-to-grasp, explanations of mRNA vaccine technology, development, testing and safety protocols, and potential side effects. Participants were randomised into three groups: (1) a control group who watched an unrelated placebo video, (2) a “video-optional” group for whom every informational video was optional, and (3) a “video-required” group for whom the vaccine-technology video was mandatory, but all other videos were optional. Primary endpoints were future vaccine uptake intentions, vaccine efficacy beliefs, and vaccine side-effect concerns (all measured on a 100-point scale). Secondary endpoints measured information-seeking behaviour and trust in health care professionals. The trial was registered on ISRCTN (ISRCTN98065390), and pre-registered on the AEA RCT registry (AEARCTR0008909).

Results Relative to control (3,014 participants), the video-optional group (1,320 participants) exhibited a 0·09 standard deviation (95% CI: 0·02-0·15) improvement in vaccine intentions, a 0·10 SD (95% CI: 0·03-0·17) improvement in vaccine-efficacy beliefs, and a 0·14 SD (95% CI: 0·07-0·21) improvement in side-effect concerns.  The video-required group (2,756 participants) yielded improvements, relative to control, of 0·07, 0·18, and 0·08 SDs in the respective categories (95% CIs: 0·02-0·12, 0·13-0·23, 0·03-0·13).  55-60% of the participants in both treatment groups watched optional videos.

Interpretation Wilful avoidance of vaccine information does not appear to explain entrenched vaccine hesitancy. Impartial and detailed information may be an effective communication and policy tool.

Trial Registration The trial was registered on ISRCTN (ISRCTN98065390), and pre-registered on the AEA RCT registry (AEARCTR0008909).

Funding The British Academy (award reference CRUSA210024).

Declaration of Interest We declare no competing interests.

Ethical Approval The University of Nottingham School of Economics Ethics Committee reviewed and approved the survey-experiment. This report follows CONSORT randomised trial reporting guidelines. Participants were required to affirm consent on the first survey screen.

Keywords: Vaccine hesitancy, informational intervention, behavioral intervention

Suggested Citation

Martinez, Seung-Keun and Sonderegger, Silvia and Brownback, Andy and Cruces, Guillermo and Pompeo, Monika and Morling, Joanne R., Effect of Informational Videos on Vaccine Perceptions Among Unvaccinated Individuals: A Randomized Control Trial. Available at SSRN: https://ssrn.com/abstract=4611489 or http://dx.doi.org/10.2139/ssrn.4611489

Seung-Keun Martinez

University of Nottingham ( email )

Sir Clive Granger Building
Universit Park
Nottingham, Nottinghamshire NG72RD
United Kingdom

Silvia Sonderegger

University of Nottingham ( email )

University Park
Nottingham, NG8 1BB
United Kingdom

Andy Brownback

University of Arkansas ( email )

Fayetteville, AR 72701
United States

Guillermo Cruces (Contact Author)

Universidad Nacional de La Plata - Centro de Estudios Distributivos, Laborales y Sociales (CEDLAS) ( email )

Centro de Estudios Distributivos, Laborales y
Sociales, Calle 6 e/47 y 48
La Plata, Provincia de Buenos Aires 1900
Argentina

HOME PAGE: http://cedlas.econo.unlp.edu.ar

IZA

P.O. Box 7240
Bonn, D-53072
Germany

Monika Pompeo

New York University (NYU) - New York University, Abu Dhabi ( email )

PO Box 129188
Abu Dhabi
United Arab Emirates

Joanne R. Morling

University of Nottingham ( email )

University Park
Nottingham, NG8 1BB
United Kingdom

Click here to go to TheLancet.com

Paper statistics

Downloads
56
Abstract Views
255
PlumX Metrics