Plasma Levels and Dietary Intake of Minerals in Patients with Type 2 Diabetes and Chronic Kidney Disease
21 Pages Posted: 7 Nov 2023
Abstract
Background: Diabetic kidney disease (DKD) is the primary cause of chronic kidney disease (CKD) worldwide. Altered mineral levels leading to adverse outcomes are widely reported in diabetes, but studies regarding their status in DKD are limited.
Methods: To explore the status of minerals, a hospital-based case-control study was taken up with 54 healthy controls (C) and 140 subjects with type 2 diabetes wherein 74 subjects with diabetes, and CKD formed the DKD group, and 66 subjects with diabetes, no CKD formed the DNCKD group. High-resolution inductively coupled plasma mass spectrometry was used to evaluate the blood levels of minerals (Ca, V, Cr, Mn, Fe, Co, Cu, Zn, and Se), and raw food-based food frequency questionnaire for dietary intakes.
Results: The median values of plasma Ca in the DKD group were significantly lower compared with the DNCKD and C groups (10.5 mg/dL vs. 11.0 mg/dL and 11.7 mg/dL, p<0.001). Furthermore, plasma Ca levels lowered with declining kidney function, as evidenced by the estimated glomerular filtration rate (eGFR) and albuminuria segregation. Dietary intake of minerals did not correlate with the corresponding plasma levels. However, in the DKD group, eGFR correlated positively with the plasma levels of Ca (r= 0.422, p=0.001), Cr (r= 0.351, p=0.008), Mn (r= 0.338, p=0.011), Fe (r= 0.403, p=0.002), Cu (r= 0.274, p=0.041) and negatively with Se (r= -0.486, p<0.001).Conclusion: Plasma calcium levels are lower in the DKD group with a strong positive association with eGFR, indicating its role in predicting the onset and progression of kidney function decline.
Note:
Funding Declaration: GBR acknowledges the financial assistance from the Department of Science and Technology, Government of India
(Grant #SB/SO/HS-192/2013) and the Department of Biotechnology, Government of India (Grant #
BT/PR10658/PFN/20/806/2013).
M Sivaprasad and TS acknowledge the research fellowship from the Indian Council of Medical Research, Government
of India.
Conflicts of Interest: None
Ethical Approval: This study was performed in line with the principles of the Declaration of Helsinki. All the
procedures involving the patients were approved by the Ethics Committee of the ICMR-National Institute of Nutrition
and Osmania Medical College and General Hospital, Hyderabad. Written informed consent was obtained from all individual participants included in the study. The authors confirm that human research participants provided informed consent for publication.
Keywords: Minerals, Trace elements, Diabetes, Chronic kidney disease, Diabetic kidney disease, Dietary intake
Suggested Citation: Suggested Citation