NIR Response Multifunctional Core-Shell Nanoparticles for Synergistic Photothermal Therapy and Chemotherapy Applications

Abstract

In the study, the multifunctional nanohybrids comprising magnetic nanoparticles Mn0.7Zn0.3Fe2O4 coated with a light-absorbing polymer responsive to near-infrared (NIR) radiation are successfully synthesized, then the nanocomposite is functionalized with NH2 to obtain Mn0.7Zn0.3Fe2O4@mSiO2-NH2 (MZFSs-NH2) nanoparticles. The results shown the core-shell MZFSs-NH2 demonstrates effective photothermal stability and the photothermal conversion efficiency, the temperature rise of magnetic heating can reach to 32.3℃, 36.8℃ and 42.4 ℃ in different MZFSs-NH2 concentrations, which are higher than water(2.1 ℃) under the same NIR laser irradiation, the photothermal conversion efficiency can reach to 19.6%. The adsorption energy of SiO2 and -NH2 modified SiO2 with DOX are 25.99 kcal/mol and -154.84 kcal/mol, which corresponding to endothermic process and exothermic process respectively. The -NH2 modified SiO2 shell exhibits the capability to encapsulate therapeutic molecules with aromatic structures DOX. The core-shell Mn0.7Zn0.3Fe2O4@mSiO2-NH2 (MZFSs-NH2) nanocomposite is a promising candidate for synergistic magneto-photothermal therapy and chemotherapy. The research findings offer a promising approach for efficient treatment (synergistic photothermal therapy and chemotherapy) for cancer therapy.

Keywords: Photothermal therapy, Magnetic hyperthermia, Core-Shell Nanoparticles, NIR Response, Drug affinity