Electrochemical Detection of Antimalarial Drug (Amodiaquine) Using Dy-Mof@Mwcnt Composites to Prevent Erythrocytic Stages of Plasmodium Species in Human Bodies

Abstract

Herein, we report the dysprosium-based metal-organic framework (Dy-MOF) @multiwalled carbon nanotubes (MWCNT) Composites modified with glassy carbon electrode (Dy-MOF@MWCNT/GC) as a working electrode for Antimalarial drug detection. Dy-MOF@MWCNT composites was prepared using sonochemical process along with ultrasonication. The composite structure, phase purity, morphology and composition of the composites were confirmed by X-ray diffraction, Scanning electron microscope, and X-ray photoelectron spectroscopy. Further, Dy@MWCNT composites were deposited on a glassy carbon electrode by drop casting method, and used as an electrode material to efficiently detect Amodiaquine (ADD) by electrochemical techniques such as CV and DPV. The as-prepared Dy@MWCNT composite material showed the oxidation peak current of ADD to be ~ 60% higher than other unmodified GC electrodes and showed a low charge transfer resistance (R ct) of 24 Ω. The Dy@MWCNT provided a broad linear range of 0.4 to 2 M with a limit of detection 0.377 μM and sensitivity 1.817 μA.μM-1 for the detection of ADD. According to the pH study, the amount of electrons and protons involved in the electrochemical processes of ADD was calculated and a plausible mechanism for ADD electro-oxidation was proposed. Thus, the prepared sensor exhibited practical usefulness by determining the ADD drug in human urine samples. Hence, the results shows that the Dy@MWCNT- modified sensor has good electrocatalytic activity for the redox of ADD.

Keywords: Amodiaquine, Carbon nanomaterials, Metal organic framework, Electrochemical sensor, Antimalarial drug