Correlation Analysis of Secondary Metabolites and Disease Resistance Activity of Different Varieties of Congou Black Tea Based on Gc-Ms/Ms and Tcmsp

Abstract

To investigate the correlation between the difference of secondary metabolites and the disease resistance activity of different varieties of Congou black tea. Among a total of 657 secondary metabolites identified, 183 metabolites had anti-disease activity, 113 were key active ingredients in traditional Chinese medicine (TCM), 73.22% had multiple anti-disease activities, and all were mainly flavonoids and phenolic acids. The main enriched metabolic pathways were phenylpropanoid biosynthesis, biosynthesis of secondary metabolites, flavonoid biosynthesis, and metabolic pathways. Flavonoid and phenolic acid secondary metabolites were more correlated with anti-disease activity and key active TCM ingredients. Conclusion: Types of secondary metabolites are consistent among different varieties Congou black-tea, while the relative contents differ significantly, with JGY and Q601 showing large differences in secondary metabolites. Flavonoid and phenolic acid secondary metabolites were the main reasons for the difference of secondary metabolites and the more correlation of disease resistance activity among different varieties of  black tea.

Keywords: Congou black tea, secondary metabolites, Metabolomics, disease-resistance activity, correlation