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THER: Integrative Web Tool for Tumor Hypoxia Exploration and Research
23 Pages Posted: 29 Dec 2023
More...Abstract
Background: Hypoxia is an important factor in the adaptation of tumor cells to their environment, contributes to their malignant progression, and affects tumor prognosis and drug sensitivity. Although there is a wealth of transcriptomic data stored in public databases, there is a lack of web-based tools for analyzing these data to explore the link between hypoxia and the mechanisms of tumorigenesis and progression.
Methods: We have developed an interactive web-based tool called THER, which is designed to help users easily identify potential targets, mechanisms of action and effective drugs for treating hypoxic tumors. THER integrates 63 transcriptomic tumor hypoxia datasets from the Gene Expression Omnibus (GEO) database, covering 3 species, 18 tumor types and 42 cell line types.
Findings: This web tool provides five modules that allow users to perform differential expression analysis, expression profiling analysis, correlation analysis, enrichment analysis and drug sensitivity analysis on different datasets based on different oxygen statuses. Users can use these modules to autonomously explore various features in tumor samples under hypoxia/normoxia conditions to investigate the changes that occur in tumors in hypoxic environments.
Interpretation: We expect that users will be able to use the tool to identify valuable biomarkers, further reveal the molecular mechanisms of tumor hypoxia, and identify effective drugs, thus providing a scientific basis for tumor diagnosis and treatment. THER is open to all users and can be accessed without login at https://smuonco.shinyapps.io/THER/.
Funding: None.
Declaration of Interest: The authors declare no conflict of interest.
Keywords: hypoxia tumor, biomarkers, molecular mechanisms, effective drugs, web tool
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