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Seroprevalence of Pertussis in Chinese Population During 2010-2022: A Systematic Review and Meta-Analysis
25 Pages Posted: 29 Dec 2023
More...Abstract
Background: Pertussis is a vaccine-preventable infectious disease, however, data on pertussis antibody levels in a nationwide population are still limited in China. We aimed to pool seropositive rate of antibody against pertussis toxin (PT-IgG) among Chinese population.
Methods: We systematically searched PubMed, Web of Science, Embase, and China National Knowledge Infrastructure Database for studies published between 1 January 2010 and 30 June 2023. The studies reporting seroprevalence on PT-IgG among healthy Chinese population are included. Pooled estimates were obtained using random-effect meta-analyses. The age-specific estimates in different years were used meta-regression.
Findings: Thirty-nine studies involving 47 778 subjects reporting the seropositive rates of anti-PT IgG were included in the meta-analysis. The pooled seropositive rate in the whole population was 7.06% (95% CI, 5.50%-9.07%). In subgroup meta-analyses, the estimates were 8.71%, 12.50%, 8.15%, 8.96%, 8.90% ,6.36% and 8.96% for people y aged <1, 1-2, 3-4, 5-9, 10-19, 20-39, and ≥40 years, respectively. The highest estimate was 11.89% for subjects in East China, but the lowest estimate was 6.36% for those in Southwestern China. A trend of decreasing seropositive rate of anti-PT IgG was observed during the past eight years, with a relative decreasing rate of 56.82% to 58.50% from 2012 to 2020. In 2020, the seropositive rate ranged from 7.22% (95% CI, 4.62%-11.11%) among children younger than 1 year old to 5.99% (95% CI, 3.94%-9.02%) among adults aged 40 years and older.
Interpretation: This meta-analysis showed a low seropositive rate of anti-PT IgG in the Chinese population, especially in school-age children and young adult, highlighting the urgent need for great efforts to optimize the immunization strategy.
Funding: This work was supported by the Zhejiang Provincial Medical and Health Science and Technology Project (grant number 2024KY885).
Declaration of Interest: The authors declare no conflicts of interest.
Keywords: Pertussis, Antibodies, Pertussis toxin, China, Meta-analysis
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