Fabrication and Characterization of Porous Pectin-Based Aerogels for Drug Delivery

29 Pages Posted: 24 Jan 2024

See all articles by Supakij Suttiruengwong

Supakij Suttiruengwong

Silpakorn University

Srisuda Konthong

Silpakorn University

Sommai Pivsa-Art

Rajamangala University of Technology Thanyaburi

Pornsinee Plukchaihan

Silpakorn University

Pitsopa Meesuwan

Silpakorn University

Monthira Wanthong

Silpakorn University

Nuttada Panpradist

University of Washington

Rittin Abraham Kurien

Saintgits College of Engineering

Phakkhannan Pakawanit

Synchrotron Light Research Institute

Pornsak Sriamornsak

Silpakorn University

Abstract

This study aimed to prepare pectin-based aerogels and demonstrate their application as a drug delivery system for two drugs; ibuprofen and diclofenac sodium. Drug-loaded low methoxy pectin solution was added to calcium chloride solution to form hydrogels. The drug-loaded pectin-based hydrogels were dehydrated in acetonitrile-water and subsequently dried using either supercritical carbon dioxide (scCO2) or freeze-drying. The scCO2-dried, pectin-based aerogels had 0.27% less shrinkage than freeze-dried aerogels. SEM micrographs revealed both aerogels had high porosity with Type IV isotherms and mesoporous characteristics. However, scCO2-dried, pectin-based aerogels presented a higher specific surface area and pore volume, and a smaller pore diameter than freeze-dried aerogels. The pectin-based aerogels had similar thermal degradation to bulk pectin, and FTIR spectra revealed no interaction between the loaded drug and pectin-based aerogels. The loading of ibuprofen in scCO2-dried, pectin-based aerogels at 90, 95, and 100 bar were 60.0%, 59.9%, and 52.1%, respectively, and the loading of diclofenac sodium was 38.37%. At  90, 95, and 100 bar, ibuprofen-loaded pectin-based aerogels were released at 90.0%, 84.0%, and 75.5%, respectively. In contrast, the release of diclofenac sodium-loaded, pectin-based aerogels was at 88.4%. Korsmeyer-Peppas model was fitted for both ibuprofen and diclofenac sodium, indicating the release mainly driven by diffusion.

Keywords: Hydrogels, pectin, Aerogels, Supercritical fluid carbon dioxide, Specific surface area

Suggested Citation

Suttiruengwong, Supakij and Konthong, Srisuda and Pivsa-Art, Sommai and Plukchaihan, Pornsinee and Meesuwan, Pitsopa and Wanthong, Monthira and Panpradist, Nuttada and Kurien, Rittin Abraham and Pakawanit, Phakkhannan and Sriamornsak, Pornsak, Fabrication and Characterization of Porous Pectin-Based Aerogels for Drug Delivery. Available at SSRN: https://ssrn.com/abstract=4690705 or http://dx.doi.org/10.2139/ssrn.4690705

Srisuda Konthong

Silpakorn University ( email )

Sommai Pivsa-Art

Rajamangala University of Technology Thanyaburi ( email )

Thailand

Pornsinee Plukchaihan

Silpakorn University ( email )

Pitsopa Meesuwan

Silpakorn University ( email )

Monthira Wanthong

Silpakorn University ( email )

Nuttada Panpradist

University of Washington

Rittin Abraham Kurien

Saintgits College of Engineering ( email )

Kottayam
India

Phakkhannan Pakawanit

Synchrotron Light Research Institute ( email )

Nakhon Ratchasima
Thailand

Pornsak Sriamornsak

Silpakorn University ( email )

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