Horses with Previous Episodes of Laminitis Have Altered Insulin Responses to Seasonal Oral Sugar Testing and Grazing Compared to Horses with No Known History of Laminitis

28 Pages Posted: 24 Jan 2024

See all articles by Katelyn L. Kaufman

Katelyn L. Kaufman

Morehead State University

Jessica K. Suagee-Bedore

affiliation not provided to SSRN

Sally E. Johnson

affiliation not provided to SSRN

Kristine M. Ely

affiliation not provided to SSRN

Shayan J. Ghajar

Oregon State University

Bridgett M. McIntosh

affiliation not provided to SSRN

Abstract

Forage is essential to the equine diet for health and performance but intake of elevated pasture nonstructural carbohydrates (NSC) can cause metabolic dysfunction. This study aimed to investigate influence of laminitis history on metabolic and morphometric responses in grazing horses. Twelve mares (15 ± 3.4 yrs) were selected based on previous diagnosis of laminitis (PRELAM; n=6) or not (NOLAM; n=6). Horses were maintained on 8.5-ha pasture and weekly pasture samples were clipped at random for nutrient analysis. Weekly blood samples were collected and analyzed for glucose and insulin concentrations, and body weight (BW), body condition score (BCS), and cresty neck score (CNS) were evaluated weekly. Monthly, a modified oral sugar test (OST) was used to assess basal (T0) and 75-minute (T75) insulin dynamics following 0.30 mL/kg BW Karo Light Corn Syrup. Data were analyzed using PROC MIXED with repeated measures in SAS. PRELAM had greater CNS (P < 0.001), BW (P < 0.05), and BCS compared to NOLAM (P < 0.05). Non-fasted glucose was influenced by month (P < 0.001) while non-fasted insulin was affected by group by month (P = 0.004). Fasted insulin concentrations (T0) were affected by month and group (P < 0.001) whereas PRELAM had greater concentrations. T75 glucose and insulin concentrations were affected by month (P < 0.001 and P = 0.002, respectively) and were higher for PRELAM (P = 0.003). These data suggest horses with greater general and regional adiposity, and previous history of laminitis, exhibit greater insulin concentrations in response to grazing and OST.

Keywords: Seasonal, Insulin Dysregulation, OST, NSC

Suggested Citation

Kaufman, Katelyn L. and Suagee-Bedore, Jessica K. and Johnson, Sally E. and Ely, Kristine M. and Ghajar, Shayan J. and McIntosh, Bridgett M., Horses with Previous Episodes of Laminitis Have Altered Insulin Responses to Seasonal Oral Sugar Testing and Grazing Compared to Horses with No Known History of Laminitis. Available at SSRN: https://ssrn.com/abstract=4704696 or http://dx.doi.org/10.2139/ssrn.4704696

Katelyn L. Kaufman (Contact Author)

Morehead State University ( email )

Morehead, KY 40351
United States

Jessica K. Suagee-Bedore

affiliation not provided to SSRN ( email )

No Address Available

Sally E. Johnson

affiliation not provided to SSRN ( email )

No Address Available

Kristine M. Ely

affiliation not provided to SSRN ( email )

No Address Available

Shayan J. Ghajar

Oregon State University ( email )

Bexell Hall 200
Corvallis, OR 97331
United States

Bridgett M. McIntosh

affiliation not provided to SSRN ( email )

No Address Available

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